Use of extracorporeal blood purification therapy (ECBPT) as an adjuvant to high-dose corticosteroids in a severely ill COVID-19 patient with concomitant bacterial infection

COVID-19 presents with a spectrum of severity, ranging from asymptomatic or mild symptoms to those with acute respiratory distress syndrome. Corticosteroids are widely used for their efficacy in reducing inflammatory responses. However, its use may be limited to patients with immunosuppression. An a...

Full description

Saved in:
Bibliographic Details
Published in:BMJ case reports 2021-10, Vol.14 (10), p.e245639
Main Authors: Lim, Min Xian, Fong, Kean Khang, Yeap, Tat Boon
Format: Article
Language:English
Subjects:
Bacterial infections
Case Report
Case reports
Coronaviruses
COVID-19
Cytokines
Fever
Hemodynamics
Illnesses
Infections
Intensive care
Lungs
Mortality
Pathophysiology
Patients
Pneumonia
Renal replacement therapy
Severe acute respiratory syndrome coronavirus 2
Steroids
Viral infections
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:COVID-19 presents with a spectrum of severity, ranging from asymptomatic or mild symptoms to those with acute respiratory distress syndrome. Corticosteroids are widely used for their efficacy in reducing inflammatory responses. However, its use may be limited to patients with immunosuppression. An adjunct therapy for cytokine storm in COVID-19 is extracorporeal blood purification therapies using high adsorptive filters, such as oXiris, to remove cytokines. We share our experience in using continuous renal replacement therapy with oXiris haemofilter as a temporising measure to high-dose corticosteroids in managing cytokine storm in a deteriorating COVID-19 patient with concomitant bacterial infection.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2021-245639