Poor response at restaging MRI and high incomplete resection rates of locally advanced mucinous rectal cancer after chemoradiation therapy

• Published in: Colorectal disease 2021-09, Vol.23 (9), p.2341-2347
• Main Authors: Koëter, Tijmen, Stijns, Rutger C. H., Koeverden, Sebastiaan, Hugen, Niek, Heijden, Joost Albertus Gerardus, Nederend, Joost, Zwam, Peter H., Nagtegaal, Iris D., Verheij, Marcel, Rutten, Harm J. T., Wilt, Johannes H. W.
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Chemoradiotherapy; Colorectal cancer; Fascia; locally advanced; Magnetic resonance imaging; MRI; mucinous rectal cancer; neoadjuvant treatment; Original; Patients; rectal cancer; Rectum; response evaluation; Survival
• ISSN: 1462-8910; 1463-1318
• DOI: 10.1111/codi.15760

Aim Mucinous carcinoma is a histological subtype of rectal cancer and has been associated with a poor response to neoadjuvant chemoradiotherapy (CRT). The primary aim of this study was to analyse the response on MRI of mucinous locally advanced rectal cancer (LARC) after CRT compared to regular adenocarcinoma. Method Patients with LARC (defined as cT4 and/or cN2), who underwent CRT followed by restaging MRI and surgery in two tertiary referral hospitals were retrospectively included in the study. Pre‐ and post‐treatment MRI was reviewed by an experienced abdominal radiologist. Results A total of 102 patients, of whom 29 were diagnosed with mucinous carcinoma, were included for analysis. At restaging MRI, adenocarcinoma patients demonstrated significantly less clinical involvement of the mesorectal fascia (37% vs. 62%, P = 0.003) while this was not demonstrated in mucinous carcinoma patients (86% vs. 97%, P = 0.16). Significant downstaging after CRT in adenocarcinoma patients (P = 0.01) was seen while, in mucinous carcinoma patients, no downstaging after CRT (P = 0.89) was seen. Pathology revealed significantly higher rates of an involved circumferential resection margin in mucinous carcinoma versus adenocarcinoma patients (27.6% vs. 1.4%; P