Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma

Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for >30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an aver...

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Bibliographic Details
Published in:Journal of Clinical and Experimental Hematopathology 2021, Vol.61(3), pp.168-172
Main Authors: Furukawa, Yoshiki, Ando, Jun, Ando, Miki, Kinoshita, Shintaro, Edahiro, Yoko, Furuta, Takuya, Ohshima, Koichi, Komatsu, Norio
Format: Article
Language:English
Subjects:
Case Report
diffuse large B-cell lymphoma
long-term remission
Spontaneous regression
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Summary:Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for >30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an average SR duration of 13 mo. As the cause of SR is unknown, there are many theories such as trauma, infection, medication, and an antitumor immune response. We present a patient with progressive DLBCL who demonstrated SR for >42 mo. Although treatment for lymphoma usually starts soon after diagnosis, insights into SR of lymphomas may lead to new treatment strategies.
ISSN:1346-4280
1880-9952
DOI:10.3960/jslrt.21002