Pictorial review of whole body MRI in myeloma: emphasis on diffusion-weighted imaging

There have been major advances in myeloma imaging over the past few years with focal lesions on imaging now forming part of the disease defining criteria. Whole body diffusion-weighted MRI (WB-MRI) is considered the most sensitive technique for the detection of focal active lesions. This pictorial r...

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Bibliographic Details
Published in:British journal of radiology 2020-11, Vol.93 (1115), p.20200312-20200312
Main Authors: Hameed, Maira, Sandhu, Amandeep, Soneji, Neil, Amiras, Dimitri, Rockall, Andrea, Messiou, Christina, Wallitt, Kathryn, Barwick, Tara D
Format: Article
Language:English
Subjects:
Aged
Bone Marrow - diagnostic imaging
Bone Marrow Neoplasms - diagnostic imaging
Bone Marrow Neoplasms - therapy
Diffusion Magnetic Resonance Imaging - methods
Female
Humans
Incidental Findings
Magnetic Resonance Imaging - methods
Male
Middle Aged
Multiple Myeloma - diagnostic imaging
Multiple Myeloma - therapy
Pictorial Review
Plasmacytoma - diagnostic imaging
Whole Body Imaging - methods
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Summary:There have been major advances in myeloma imaging over the past few years with focal lesions on imaging now forming part of the disease defining criteria. Whole body diffusion-weighted MRI (WB-MRI) is considered the most sensitive technique for the detection of focal active lesions. This pictorial review will focus on imaging the spectrum of myelomatous disorders on WB-MRI including diffusion and Dixon sequences. The typical imaging patterns of disease are demonstrated including in the contexts of staging, presumed solitary plasmacytoma, smouldering myeloma and examples of paramedullary and extramedullary disease. The utility of diffusion-weighted imaging in response assessment is a major advantage and this will be exemplified here.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr.20200312