Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study

Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug re...

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Bibliographic Details
Published in:Diabetes therapy 2021-11, Vol.12 (11), p.2873-2889
Main Authors: Terui, Sakiko, Akamatsu, Ryoichi, Arai, Masanori, Inoue, Ryota, Okuyama, Tomoko, Kyohara, Mayu, Li, Jinghe, Tsuno, Takahiro, Miyashita, Daisuke, Togashi, Yu, Terauchi, Yasuo, Shirakawa, Jun
Format: Article
Language:English
Subjects:
Antidiabetics
Cardiology
Diabetes
Drug therapy
Endocrinology
GLP-1 receptor agonists
Glucose
Insulin
Internal Medicine
Medicine
Medicine & Public Health
Observational studies
Original Research
Patient outcomes
Type 2 diabetes
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Summary:Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 ( P  
ISSN:1869-6953
1869-6961
DOI:10.1007/s13300-021-01147-2