The effect of COVID-19 derived cytokine storm on cancer cells progression: double-edged sword

• Published in: Molecular biology reports 2022-01, Vol.49 (1), p.605-615
• Main Authors: Heydarian, Mohammad, Mohammadtaghizadeh, Mohammadjavad, Shojaei, Mahboobeh, Babazadeh, Marziyeh, Abbasian, Sadegh, Amrovani, Mehran
• Format: Article
• Language: English
• Subjects: Animal Anatomy; Animal Biochemistry; Antineoplastic Agents - therapeutic use; Biomedical and Life Sciences; Cancer; Cancer therapies; Chemotherapy; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - immunology; Cytokine Release Syndrome; Cytokine storm; Drug Resistance; Histology; Humans; Life Sciences; Morphology; Neoplasms - drug therapy; Patients; Review; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Tumor cells
• ISSN: 0301-4851; 1573-4978; 1573-4978
• DOI: 10.1007/s11033-021-06800-4

Objective Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) was first detected in Wuhan, China in December, 2019. The emerging virus causes a respiratory illness, that can trigger a cytokine storm in the body. Method Cytokine storm in patient’s body is associated with severe forms of disease. It is one of the main complications of coronavirus disease-2019 (COVID-19), in which immune cells play a major role. Studies have shown immune cells in the tumor environment can be effective to induce resistance to chemotherapy in cancer patients. Result Therefore, considering the role of immune cells to induce cytokine storm in COVID-19 patients, and their role to cause resistance to chemotherapy, they are effective on disease progression and creation of severe form of disease. Conclusion By examining the signaling pathways and inducing resistance to chemotherapy in tumor cells and the cells affect them, it is possible to prevent the occurrence of severe forms of the disease in cancer patients with COVID-19; it is applicable using target therapy and other subsequent treatment strategies.