Estimation of the time of death by measuring the variation of lateral cerebral ventricle volume and cerebrospinal fluid radiodensity using postmortem computed tomography

Using postmortem CT (PMCT), changes in the volume of the lateral cerebral ventricles (LCVs) and modifications of the radiodensity of cerebrospinal fluid (CSF) have been examined to identify a possible relationship between these changes and the time of death. Subsequent periodical CT scans termed “se...

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Published in:International journal of legal medicine 2021-11, Vol.135 (6), p.2615-2623
Main Authors: De-Giorgio, Fabio, Ciasca, Gabriele, Fecondo, Gennaro, Mazzini, Alberto, De Spirito, Marco, Pascali, Vincenzo L.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Autopsies
Cerebral ventricles
Cerebrospinal fluid
Cerebrospinal Fluid - diagnostic imaging
Computed tomography
Death
Female
Forensic Medicine
Humans
Investigations
Lateral Ventricles - diagnostic imaging
Legal medicine
Linear Models
Male
Medical imaging
Medical Law
Medicine
Medicine & Public Health
Middle Aged
Original
Original Article
Postmortem Changes
Segmentation
Time Factors
Tomography, X-Ray Computed
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creator De-Giorgio, Fabio
Ciasca, Gabriele
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De Spirito, Marco
Pascali, Vincenzo L.
description Using postmortem CT (PMCT), changes in the volume of the lateral cerebral ventricles (LCVs) and modifications of the radiodensity of cerebrospinal fluid (CSF) have been examined to identify a possible relationship between these changes and the time of death. Subsequent periodical CT scans termed “sequential scans” for ten corpses at known time of death were obtained, and a 3D segmentation of the entire LCV was carried out to measure its volume and radiodensity over time from ~ 5.5- h up to 273-h postmortem. A linear decrease of the LCV volume for all the cases was observed in the investigated time range, together with an overall logarithmic increase of radiodensity. Although a larger sampling should be performed to improve the result reliability, our finding suggests that the postmortem variation of CSF radiodensity can be a potentially useful tool in determining postmortem interval, a finding that is worthy of further investigation.
doi_str_mv 10.1007/s00414-021-02698-6
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source Criminology Collection; Social Science Premium Collection; Springer Nature
subjects Adult
Age
Aged
Aged, 80 and over
Autopsies
Cerebral ventricles
Cerebrospinal fluid
Cerebrospinal Fluid - diagnostic imaging
Computed tomography
Death
Female
Forensic Medicine
Humans
Investigations
Lateral Ventricles - diagnostic imaging
Legal medicine
Linear Models
Male
Medical imaging
Medical Law
Medicine
Medicine & Public Health
Middle Aged
Original
Original Article
Postmortem Changes
Segmentation
Time Factors
Tomography, X-Ray Computed
title Estimation of the time of death by measuring the variation of lateral cerebral ventricle volume and cerebrospinal fluid radiodensity using postmortem computed tomography
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