An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors

Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer types. However, no systematic pan-cancer analysis has been performed to date. Therefore, the present study analyzed the potential oncogenic role of COPB2 using TCGA (The Cance...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2021, Vol.2021, p.7405322-18
Main Authors: Wu, Biao, Wu, Yumeng, Guo, Xianlin, Yue, Yanping, Li, Yuanyuan, He, Xiao, Chen, Yuanbin, Zhao, Wenjing, Liu, Jibin, Wu, Xuming, Shen, Aiguo, Zhang, Suqing
Format: Article
Language:English
Subjects:
Analysis
Binding proteins
Biomedical research
Breast
Cancer
Carcinogenesis
Cervix
Chemotherapy
Coatomer Protein - genetics
Coatomer Protein - metabolism
Colon
Computational Biology
Databases, Genetic
Datasets
Diagnosis
Endometrial cancer
Endometrium
Fibroblasts
Gene expression
Genetic aspects
Genomes
Health aspects
Humans
Identification and classification
Molecular Targeted Therapy - methods
Mutation
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Oncogenes
Ovarian cancer
Physiological aspects
Prognosis
Proteins
Survival Rate
Transforming growth factors
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer types. However, no systematic pan-cancer analysis has been performed to date. Therefore, the present study analyzed the potential oncogenic role of COPB2 using TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) datasets. The majority of the cancer types overexpressed the COPB2 protein, and its expression significantly correlated with tumor prognosis. In certain tumors, such as those found in breast and ovarian tissues, phosphorylated S859 exhibited high expression. It was found that mutations of the COPB2 protein in kidney and endometrial cancers exhibited a significant impact on patient prognosis. It is interesting to note that COPB2 expression correlated with the number of cancer-associated fibroblasts in certain tumors, such as cervical and endocervical cancers and colon adenocarcinomas. In addition, COPB2 was involved in the transport of substances and correlated with chemotherapy sensitivity. This is considered the first pan-tumor study, which provided a relatively comprehensive understanding of the mechanism by which COPB2 promotes cancer growth.
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/7405322