Thyroid disease and hypothyroidism are associated with poor COVID-19 outcomes: A systematic review, meta-analysis, and meta-regression

Coronavirus disease (COVID-19) still becomes a global burden that affected people in different groups. The aim of this study was to evaluate the association between thyroid disease and the outcome of COVID-19 patients. This was a meta-analysis study from articles obtained through a systematic litera...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2021-11, Vol.15 (6), p.102312-102312, Article 102312
Main Authors: Damara, Fachreza Aryo, Muchamad, Galih Ricci, Ikhsani, Rizkania, Hendro, Syafiyah, Anisa Hana, Bashari, Muhammad Hasan
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 - complications
Humans
Hyperthyroidism
Hypothyroidism
Hypothyroidism - complications
Outcome
Regression Analysis
Review
Thyroid disease
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Summary:Coronavirus disease (COVID-19) still becomes a global burden that affected people in different groups. The aim of this study was to evaluate the association between thyroid disease and the outcome of COVID-19 patients. This was a meta-analysis study from articles obtained through a systematic literature search to investigate the relationship between thyroid disease and COVID-19 outcomes. Composite poor outcomes comprised of severity, mortality, intensive care unit (ICU) admission, and hospitalization. A total of 31339 patients from 21 studies included in this study. Thyroid disorder was associated with increased composite poor outcome (risk ratio (RR) 1.87 [95% confidence interval (CI) 1.53, 2.27], p 
ISSN:1871-4021
1878-0334
1878-0334
DOI:10.1016/j.dsx.2021.102312