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Quantitative magnetic resonance imaging of meniscal pathology ex vivo

Objective To determine the ability of conventional spin echo (SE) T2 and ultrashort echo time (UTE) T2* relaxation times to characterize pathology in cadaveric meniscus samples. Materials and methods From 10 human donors, 54 triangular (radially cut) meniscus samples were harvested. Meniscal patholo...

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Bibliographic Details
Published in:Skeletal radiology 2021-12, Vol.50 (12), p.2405-2414
Main Authors: Bae, Won C., Tadros, Anthony S., Finkenstaedt, Tim, Du, Jiang, Statum, Sheronda, Chung, Christine B.
Format: Article
Language:English
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Summary:Objective To determine the ability of conventional spin echo (SE) T2 and ultrashort echo time (UTE) T2* relaxation times to characterize pathology in cadaveric meniscus samples. Materials and methods From 10 human donors, 54 triangular (radially cut) meniscus samples were harvested. Meniscal pathology was classified as normal ( n  = 17), intrasubstance degenerated ( n  = 33), or torn ( n  = 4) using a modified arthroscopic grading system. Using a 3-T MR system, SE T2 and UTE T2* values of the menisci were determined, followed by histopathology. Effect of meniscal pathology on relaxation times and histology scores were determined, along with correlation between relaxation times and histology scores. Results Mean ± standard deviation UTE T2* values for normal, degenerated, and torn menisci were 3.6 ± 1.3 ms, 7.4 ± 2.5 ms, and 9.8 ± 5.7 ms, respectively, being significantly higher in degenerated ( p   0.14). In terms of histology, we found significant group-wise differences (each p  
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-021-03808-6