The incidence of psoriasis among smokers and/or former smokers inflammatory bowel diseases patients treated with tumor necrosis factor antagonist: A systematic review and meta-analysis

Infliximab (IFX) and adalimumab (ADA) refer to the classic drugs to treat moderate-severe inflammatory bowel disease (IBD), which have been proven to be effective to control IBD. However, the side effects exerted by IFX and ADA should be monitored in therapies, especially the paradoxical reaction of...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2021-10, Vol.100 (42), p.e27510-e27510
Main Authors: Yang, Meiqi, Liu, Weixin, Deng, Qiuping, Liang, Zeng, Wang, Qin
Format: Article
Language:English
Subjects:
Adalimumab - therapeutic use
Gastrointestinal Agents - administration & dosage
Gastrointestinal Agents - adverse effects
Gastrointestinal Agents - therapeutic use
Humans
Incidence
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - epidemiology
Infliximab - therapeutic use
Psoriasis - drug therapy
Psoriasis - epidemiology
Risk Factors
Sex Distribution
Smokers - statistics & numerical data
Systematic Review and Meta-Analysis
Tumor Necrosis Factor Inhibitors - administration & dosage
Tumor Necrosis Factor Inhibitors - adverse effects
Tumor Necrosis Factor Inhibitors - therapeutic use
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Infliximab (IFX) and adalimumab (ADA) refer to the classic drugs to treat moderate-severe inflammatory bowel disease (IBD), which have been proven to be effective to control IBD. However, the side effects exerted by IFX and ADA should be monitored in therapies, especially the paradoxical reaction of the skin system (e.g., psoriasis). Psoriasis is recognized as the most common skin lesion, capable of significantly affecting the quality of patients' life. This study searched literatures published in English language with the qualifications on PubMed, Embase, Web of Science, Google, and Geenmedical databases. Over 2 co-authors assessed the quality of the articles and extracted the data independently. The data acquired were statistically analyzed with the statistical software of Revman and Stata. The ADA Group achieved a higher incidence of psoriasis (odds ratio [OR] = 0.658, 95% confidence interval [CI] [0.471-0.919]); Females achieved a higher incidence of psoriasis than males (OR = 1.941, 95%CI [1.326-2.843], P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000027510