Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea During Treatment: A Case Report and Literature Review

A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-p-iodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalitie...

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Bibliographic Details
Published in:Internal Medicine 2021/10/01, Vol.60(19), pp.3155-3160
Main Authors: Kitamura, Wataru, Ennishi, Daisuke, Yukawa, Ryoya, Sasaki, Ryo, Yoshida, Chikamasa, Takasuka, Hiroki, Fujiwara, Hideaki, Asada, Noboru, Nishimori, Hisakazu, Fujii, Keiko, Fujii, Nobuharu, Matsuoka, Ken-ichi, Abe, Koji, Yoshino, Tadashi, Maeda, Yoshinobu
Format: Article
Language:English
Subjects:
Aged
Blood flow
Brain
Case Report
Cerebral blood flow
Cerebrovascular Circulation
Chemotherapy
Chorea
Chorea - diagnostic imaging
Chorea - etiology
Computed tomography
Humans
Internal medicine
Iofetamine
Literature reviews
Lymphocytes T
Lymphoma
Lymphoma, T-Cell, Peripheral
Male
Neoplasm Recurrence, Local
Neostriatum
Patients
Perfusion
peripheral T-cell lymphoma
Phenotype
Phenotypes
Single photon emission computed tomography
T-cell lymphoma
T-Lymphocytes, Helper-Inducer
Tomography, Emission-Computed, Single-Photon
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Description
Summary:A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-p-iodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.7180-21