Prognostic value of the density of tumor‑infiltrating lymphocytes in colorectal cancer liver metastases

Tumor-infiltrating lymphocytes (TILs) have been reported to refect the anti-tumor immune status of patients and to be correlated with their prognosis and therapeutic outcomes. However, the characteristics of the local immune status in metastatic tumors is poorly understood, as primary tumors have be...

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Bibliographic Details
Published in:Oncology letters 2021-12, Vol.22 (6), p.1, Article 837
Main Authors: Wang, En, Nagahara, Hisashi, Fukuoka, Tatsunari, Iseki, Yasuhito, Okazaki, Yuki, Kashiwagi, Shinichiro, Tanaka, Hiroaki, Maeda, Kiyoshi
Format: Article
Language:English
Subjects:
Antibodies
Cancer
Cancer therapies
Chemotherapy
Cloning
Colorectal cancer
Health aspects
Hepatectomy
Immunohistochemistry
Liver
Lymphocytes
Medical prognosis
Metastasis
Prognosis
Tumors
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Summary:Tumor-infiltrating lymphocytes (TILs) have been reported to refect the anti-tumor immune status of patients and to be correlated with their prognosis and therapeutic outcomes. However, the characteristics of the local immune status in metastatic tumors is poorly understood, as primary tumors have been the focus in most previous studies. In addition, the local immune status may be influenced by preoperative chemotherapy. The present study aimed therefore to investigate the relationship between the degree of TIL infiltration and the prognosis in patients with curative resection of colorectal cancer liver metastases and to examine the effects of preoperative chemotherapy on the function of immune cells. A total of 108 patients who underwent curative resection of colorectal cancer liver metastases in our department between May 1996 and January 2017 were enrolled in the present study. Peripheral blood samples were obtained within two weeks before surgery. TIL infiltration was evaluated by immunohistochemical staining of surgically resected specimens of liver metastases using anti-CD8/CD3 antibodies. The mean number of TILs in five different felds was calculated, and patients were classified into a high-TIL group and a low-TIL group. Furthermore, patients were divided into three groups as follows: i) A group of patients who did not receive preoperative chemotherapy; ii) a group of patients who received short-term preoperative chemotherapy for
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2021.13098