Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?

Purpose Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced chang...

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Bibliographic Details
Published in:Sport sciences for health 2021-09, Vol.17 (3), p.753-762
Main Authors: Carter, Sophie E., Draijer, Richard, Stewart, Claire E., Moss, Andy D., Thijssen, Dick H. J., Hopkins, Nicola D.
Format: Article
Language:English
Subjects:
Bats
Carbon dioxide
Cognition & reasoning
Human Physiology
Medicine
Medicine & Public Health
Metabolic Diseases
Original
Original Article
Sports Medicine
Tumor necrosis factor-TNF
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Summary:Purpose Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced changes are related to impaired mood and cognition. Methods Twenty-five healthy desk workers (18 male, 28.3 ± 7.5 years, BMI: 24.2 ± 3.3 kg∙m −2 ) were recruited. During laboratory visit one, participants were familiarised with cognitive performance tests measuring executive function, attention and working memory. During laboratory visit two, participants completed 6 h of continuous, uninterrupted sitting. At baseline and after 6 h, serum markers of inflammation, middle cerebral artery blood flow velocity (MCAv), cerebrovascular carbon dioxide reactivity (CVR), dynamic cerebral autoregulation (CA), cognitive performance and mood (positive and negative affect, alert, contented and calm) were assessed. Data were analysed using paired-samples t tests and correlation analyses. Results Following sitting, C-reactive protein (∆-1.0 µg/ml) and tissue plasminogen activator (∆-360.4 pg/ml) decreased ( p   0.05). Conclusion Alterations in inflammation or cerebrovascular function following six hours of prolonged, uninterrupted sitting are not related to the observed reductions in mood, indicating other mechanisms underlie the relationship between acute sitting and mood disturbances.
ISSN:1824-7490
1825-1234
DOI:10.1007/s11332-021-00753-8