CAR T cell therapy in solid tumors: a short review

Summary Chimeric antigen receptor (CAR) T cell therapy has been established in the treatment of hematological malignancies. However, in solid tumors its efficacy remains limited. The aim of this article is to give an overview of the field of cell therapy itself, to introduce the underlying concepts...

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Bibliographic Details
Published in:Memo - Magazine of European medical oncology 2021-06, Vol.14 (2), p.143-149
Main Authors: Umut, Öykü, Gottschlich, Adrian, Endres, Stefan, Kobold, Sebastian
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Oncology
Review
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Summary:Summary Chimeric antigen receptor (CAR) T cell therapy has been established in the treatment of hematological malignancies. However, in solid tumors its efficacy remains limited. The aim of this article is to give an overview of the field of cell therapy itself, to introduce the underlying concepts of CAR T cell-based treatment approaches and to address its limitations in advancing the treatment for solid malignancies.
ISSN:1865-5041
1865-5076
DOI:10.1007/s12254-021-00703-7