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The effect of clamped and unclamped umbilical cord samples on blood gas analysis
Purpose Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s...
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| Published in: | Archives of gynecology and obstetrics 2021-12, Vol.304 (6), p.1493-1499 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 1499 |
| container_issue | 6 |
| container_start_page | 1493 |
| container_title | Archives of gynecology and obstetrics |
| container_volume | 304 |
| creator | Colciago, Elisabetta Fumagalli, Simona Ciarmoli, Elena Antolini, Laura Nespoli, Antonella Mastrolia, Salvatore Andrea Tagliabue, Paolo Emilio Furlan, Chiara Manganini, Cristina Vergani, Patrizia |
| description | Purpose
Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups.
Methods
A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped).
Results
There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group.
Conclusion
Samples from the unclamped cord alter the acid–base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed. |
| doi_str_mv | 10.1007/s00404-021-06076-w |
| format | article |
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Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups.
Methods
A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped).
Results
There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group.
Conclusion
Samples from the unclamped cord alter the acid–base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-021-06076-w</identifier><identifier>PMID: 34021806</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acidosis ; Approximation ; Blood Gas Analysis ; Confidence intervals ; Constriction ; Cross-Sectional Studies ; Endocrinology ; Female ; Fetal Blood ; Gases ; Gynecology ; Human Genetics ; Humans ; Infant, Newborn ; Maternal-Fetal Medicine ; Medicine ; Medicine & Public Health ; Obstetrics ; Obstetrics/Perinatology/Midwifery ; Umbilical Cord</subject><ispartof>Archives of gynecology and obstetrics, 2021-12, Vol.304 (6), p.1493-1499</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c425t-8269a4e574c252b1d76500435c80a21990fae6db538a721615fc68e9ffbf63cd3</cites><orcidid>0000-0002-0156-8429</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34021806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colciago, Elisabetta</creatorcontrib><creatorcontrib>Fumagalli, Simona</creatorcontrib><creatorcontrib>Ciarmoli, Elena</creatorcontrib><creatorcontrib>Antolini, Laura</creatorcontrib><creatorcontrib>Nespoli, Antonella</creatorcontrib><creatorcontrib>Mastrolia, Salvatore Andrea</creatorcontrib><creatorcontrib>Tagliabue, Paolo Emilio</creatorcontrib><creatorcontrib>Furlan, Chiara</creatorcontrib><creatorcontrib>Manganini, Cristina</creatorcontrib><creatorcontrib>Vergani, Patrizia</creatorcontrib><title>The effect of clamped and unclamped umbilical cord samples on blood gas analysis</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups.
Methods
A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped).
Results
There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group.
Conclusion
Samples from the unclamped cord alter the acid–base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed.</description><subject>Acidosis</subject><subject>Approximation</subject><subject>Blood Gas Analysis</subject><subject>Confidence intervals</subject><subject>Constriction</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fetal Blood</subject><subject>Gases</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal-Fetal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Umbilical Cord</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kTtPHDEUha2IKCyPP5AiskSTZsj129NEihAhkZCggNryeOxlkGe8sXdA_Hu8LJCQgsqP-51zfX0Q-kzgmACobwWAA2-AkgYkKNncf0ALwhltQBGygxbQbvYg1S7aK-UWgFCt5Se0y3gVaZALdHl147EPwbs1TgG7aMeV77GdejxPL6d57IY4OBuxS7nHpd5GX3CacBdT6vHSlqqw8aEM5QB9DDYWf_i87qPrn6dXJ7-a84uz3yc_zhvHqVg3msrWci8Ud1TQjvRKijoOE06DpaRtIVgv-04wbRUlkojgpPZtCF2QzPVsH33f-q7mbvS989M622hWeRhtfjDJDuZtZRpuzDLdGS0EU7StBl-fDXL6M_uyNuNQnI_RTj7NxVDBCCVcM1HRo__Q2zTnOvCG0oprqZSqFN1SLqdSsg-vjyFgNoGZbWCm_r15CszcV9GXf8d4lbwkVAG2BUotTUuf__Z-x_YRSQ2hQg</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Colciago, Elisabetta</creator><creator>Fumagalli, Simona</creator><creator>Ciarmoli, Elena</creator><creator>Antolini, Laura</creator><creator>Nespoli, Antonella</creator><creator>Mastrolia, Salvatore Andrea</creator><creator>Tagliabue, Paolo Emilio</creator><creator>Furlan, Chiara</creator><creator>Manganini, Cristina</creator><creator>Vergani, Patrizia</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0156-8429</orcidid></search><sort><creationdate>20211201</creationdate><title>The effect of clamped and unclamped umbilical cord samples on blood gas analysis</title><author>Colciago, Elisabetta ; Fumagalli, Simona ; Ciarmoli, Elena ; Antolini, Laura ; Nespoli, Antonella ; Mastrolia, Salvatore Andrea ; Tagliabue, Paolo Emilio ; Furlan, Chiara ; Manganini, Cristina ; Vergani, Patrizia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-8269a4e574c252b1d76500435c80a21990fae6db538a721615fc68e9ffbf63cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acidosis</topic><topic>Approximation</topic><topic>Blood Gas Analysis</topic><topic>Confidence intervals</topic><topic>Constriction</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fetal Blood</topic><topic>Gases</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal-Fetal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Umbilical Cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colciago, Elisabetta</creatorcontrib><creatorcontrib>Fumagalli, Simona</creatorcontrib><creatorcontrib>Ciarmoli, Elena</creatorcontrib><creatorcontrib>Antolini, Laura</creatorcontrib><creatorcontrib>Nespoli, Antonella</creatorcontrib><creatorcontrib>Mastrolia, Salvatore Andrea</creatorcontrib><creatorcontrib>Tagliabue, Paolo Emilio</creatorcontrib><creatorcontrib>Furlan, Chiara</creatorcontrib><creatorcontrib>Manganini, Cristina</creatorcontrib><creatorcontrib>Vergani, Patrizia</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colciago, Elisabetta</au><au>Fumagalli, Simona</au><au>Ciarmoli, Elena</au><au>Antolini, Laura</au><au>Nespoli, Antonella</au><au>Mastrolia, Salvatore Andrea</au><au>Tagliabue, Paolo Emilio</au><au>Furlan, Chiara</au><au>Manganini, Cristina</au><au>Vergani, Patrizia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of clamped and unclamped umbilical cord samples on blood gas analysis</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>304</volume><issue>6</issue><spage>1493</spage><epage>1499</epage><pages>1493-1499</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups.
Methods
A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped).
Results
There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group.
Conclusion
Samples from the unclamped cord alter the acid–base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34021806</pmid><doi>10.1007/s00404-021-06076-w</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0156-8429</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of gynecology and obstetrics, 2021-12, Vol.304 (6), p.1493-1499 |
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| source | Springer Link |
| subjects | Acidosis Approximation Blood Gas Analysis Confidence intervals Constriction Cross-Sectional Studies Endocrinology Female Fetal Blood Gases Gynecology Human Genetics Humans Infant, Newborn Maternal-Fetal Medicine Medicine Medicine & Public Health Obstetrics Obstetrics/Perinatology/Midwifery Umbilical Cord |
| title | The effect of clamped and unclamped umbilical cord samples on blood gas analysis |
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