Addressing the Osteoporosis ProblemMultifunctional Injectable Hybrid Materials for Controlling Local Bone Tissue Remodeling

• Published in: ACS applied materials & interfaces 2021-10, Vol.13 (42), p.49762-49779
• Main Authors: Gilarska, Adriana, Hinz, Alicja, Bzowska, Monika, Dyduch, Grzegorz, Kamiński, Kamil, Nowakowska, Maria, Lewandowska-Łańcucka, Joanna
• Format: Article
• Language: English
• Subjects: Amines - administration & dosage; Amines - chemistry; Amines - pharmacology; Animals; Biocompatible Materials - administration & dosage; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biological and Medical Applications of Materials and Interfaces; Bone Regeneration - drug effects; Cell Line; Chitosan - administration & dosage; Chitosan - chemistry; Chitosan - pharmacology; Collagen - administration & dosage; Collagen - chemistry; Collagen - pharmacology; Drug Liberation; Humans; Hyaluronic Acid - administration & dosage; Hyaluronic Acid - chemistry; Hyaluronic Acid - pharmacology; Injections, Subcutaneous; Materials Testing; Mice; Mice, Inbred C57BL; Osteoporosis - drug therapy; Osteoporosis - pathology; Particle Size; Silicon Dioxide - administration & dosage; Silicon Dioxide - chemistry; Silicon Dioxide - pharmacology; Tissue Engineering; Tissue Scaffolds - chemistry
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.1c17472

Novel multifunctional biomimetic injectable hybrid systems were synthesized. The physicochemical as well as biological in vitro and in vivo tests demonstrated that they are promising candidates for bone tissue regeneration. The hybrids are composed of a biopolymeric collagen/chitosan/hyaluronic acid matrix and amine group-functionalized silica particles decorated with apatite to which the alendronate molecules were coordinated. The components of these systems were integrated and stabilized by cross-linking with genipin, a compound of natural origin. They can be precisely injected into the diseased tissue in the form of a viscous sol or a partially cross-linked hydrogel, where they can serve as scaffolds for locally controlled bone tissue regeneration/remodeling by supporting the osteoblast formation/proliferation and maintaining the optimal osteoclast level. These materials lack systemic toxicity. They can be particularly useful for the repair of small osteoporotic bone defects.