Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling

The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The current animal and cell culture models do not recapitulate the functional properties of the human circulatory system, limiting our ability to fully understand the complex biol...

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Bibliographic Details
Published in:Biophysical reviews 2021-10, Vol.13 (5), p.769-786
Main Authors: Nguyen, Ngan, Thurgood, Peter, Sekar, Nadia Chandra, Chen, Sheng, Pirogova, Elena, Peter, Karlheinz, Baratchi, Sara, Khoshmanesh, Khashayar
Format: Article
Language:English
Subjects:
Animal models
Biochemistry
Biological activity
Biological and Medical Physics
Biological Techniques
Biomedical and Life Sciences
Biophysics
Cardiovascular diseases
Cardiovascular system
Cell Biology
Cell culture
Circulatory system
Drug screening
Life Sciences
Membrane Biology
Microfluidics
Nanotechnology
Review
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Summary:The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The current animal and cell culture models do not recapitulate the functional properties of the human circulatory system, limiting our ability to fully understand the complex biological processes underlying the dysfunction of this multifaceted system. In this review, we discuss the unique ability of microfluidic systems to recapitulate the biophysical, biochemical, and functional properties of the human circulatory system. We also describe the remarkable capacity of microfluidic technologies for exploring the complex mechanobiology of the cardiovascular system, mechanistic studying of cardiovascular diseases, and screening cardiovascular drugs with the additional benefit of reducing the need for animal models. We also discuss opportunities for further advancement in this exciting field.
ISSN:1867-2450
1867-2469
DOI:10.1007/s12551-021-00815-8