Changes in serum biochemical parameters of experimental Trypanosoma brucei brucei-infected Nigerian indigenous dogs administered multispecies probiotic and diminazene aceturate

Trypanosomosis is an infectious disease with great economic impact on livestock production. In this study, the effects of probiotic on serum biochemical changes of Nigerian indigenous dogs experimentally infected with Trypanosoma brucei brucei were investigated. Twenty (20) healthy dogs of both sexe...

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Bibliographic Details
Published in:Journal of parasitic diseases 2021-12, Vol.45 (4), p.1071-1076
Main Authors: Kolawole, Bamidele Jonathan, Nwoha, Rosemary Ijeoma Ogechi, Erin, Juwon Pius, Orakpoghenor, Ochuko
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alkaline phosphatase
Aspartate aminotransferase
Body weight
Creatinine
Health Promotion and Disease Prevention
Infections
Infectious Diseases
Livestock
Medicine
Medicine & Public Health
Original
Original Article
Probiotics
Protozoa
Trypanosoma brucei
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Summary:Trypanosomosis is an infectious disease with great economic impact on livestock production. In this study, the effects of probiotic on serum biochemical changes of Nigerian indigenous dogs experimentally infected with Trypanosoma brucei brucei were investigated. Twenty (20) healthy dogs of both sexes (6–10 kg body weight) following screening, were randomly divided into 5 groups of 4 dogs each. Dogs in group I (uninfected and untreated); group II (uninfected + multi species (Pet dophillus®) probiotic); group III (infected + multi species probiotic); group IV (infected + diaminazene aceturate); and group V (infected + probiotic + diminazene aceturate). Dogs were fed probiotic for 21 days before infection, and up to the last day post-infection (PI). Dogs in infected groups were inoculated intraperitonially with 2.5 × 10 6 trypanosomes on day 21 and diminazene aceturate was administered on day 5 post-infection (PI). Prepatent period and parasitaemia were determined. Blood was collected in plain sample bottles and serum harvested for serum biochemical analyses. Prepatent periods of T. brucei brucei were 4.75 ± 0.25 days (group III), 4.00 ± 0.41 days (group IV) and 4.25 ± 0.49 days (groups V); and parasitaemia was significantly decreased ( P   0.05) differences existed in the mean serum albumin and creatinine levels in all groups of dogs. The mean serum activities of alanine aminotransferase (ALT), alkaline phosphatase (ALP) and aspartate aminotransferase (AST) were increased significantly ( P  
ISSN:0971-7196
0975-0703
DOI:10.1007/s12639-021-01399-6