Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury

Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and...

Full description

Saved in:
Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.9929687-9929687
Main Authors: Zhao, Wei-kun, Zhou, Yao, Xu, Tong-tong, Wu, Qi
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Catalysis
Ferroptosis
Glutathione Peroxidase - metabolism
Homeostasis
Humans
Iron - metabolism
Ischemia
Lipid Peroxidation
Lipids
Metabolism
Metabolites
Mitochondria, Heart - metabolism
Mitochondria, Heart - pathology
Myocardial Reperfusion Injury - metabolism
Myocardial Reperfusion Injury - pathology
Myocardium - metabolism
Myocardium - pathology
Proteins
Raw materials
Reactive oxygen species
Reactive Oxygen Species - metabolism
Respiration
Review
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and excessive ROS accumulation, damaging the integrity of cell membranes. Ferroptosis is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes, and the accumulation of lipid peroxidation. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable risk event for acute myocardial infarction. Ferroptosis is closely associated with MIRI, and this relationship is discussed in detail here. This review systematically summarizes the process of ferroptosis and the latest research progress on the role of ferroptosis in MIRI to provide new ideas for the prevention and treatment of MIRI.
ISSN:1942-0900
1942-0994
DOI:10.1155/2021/9929687