Spectrum of neurological complications following COVID-19 vaccination

COVID-19 vaccines have brought us a ray of hope to effectively fight against deadly pandemic of COVID-19 and hope to save lives. Many vaccines have been granted emergency use authorizations by many countries. Post-authorization, a wide spectrum of neurological complications is continuously being rep...

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Bibliographic Details
Published in:Neurological sciences 2022-01, Vol.43 (1), p.3-40
Main Authors: Garg, Ravindra Kumar, Paliwal, Vimal Kumar
Format: Article
Language:English
Subjects:
Arthralgia
Bell's palsy
Coronaviruses
COVID-19
COVID-19 Vaccines
Demyelination
Encephalomyelitis
Female
Fever
Herpes zoster
Humans
Immunization
Medicine
Medicine & Public Health
Mimicry
mRNA
mRNA Vaccines
Myalgia
Myelitis
Neurological complications
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Pandemics
Paralysis
Polyneuropathy
Psychiatry
SARS-CoV-2
Thrombosis
Vaccination - adverse effects
Vaccines, Synthetic
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Summary:COVID-19 vaccines have brought us a ray of hope to effectively fight against deadly pandemic of COVID-19 and hope to save lives. Many vaccines have been granted emergency use authorizations by many countries. Post-authorization, a wide spectrum of neurological complications is continuously being reported following COVID-19 vaccination. Neurological adverse events following vaccination are generally mild and transient, like fever and chills, headache, fatigue, myalgia and arthralgia, or local injection site effects like swelling, redness, or pain. The most devastating neurological post-vaccination complication is cerebral venous sinus thrombosis. Cerebral venous sinus is frequently reported in females of childbearing age, generally following adenovector-based vaccination. Another major neurological complication of concern is Bell’s palsy that was reported dominantly following mRNA vaccine administration. Acute transverse myelitis, acute disseminated encephalomyelitis, and acute demyelinating polyneuropathy are other unexpected neurological adverse events that occur as result of phenomenon of molecular mimicry. Reactivation of herpes zoster in many persons, following administration of mRNA vaccines, has been also recorded. Considering the enormity of recent COVID-19-vaccinated population, the number of serious neurological events is miniscule. Large collaborative prospective studies are needed to prove or disprove causal association between vaccine and neurological adverse events occurring vaccination.
ISSN:1590-1874
1590-3478
1590-3478
DOI:10.1007/s10072-021-05662-9