Atlas of receptor genes expressed by the bovine morula and corresponding ligand‐related genes expressed by uterine endometrium

Regulation of the mammalian embryo involves cell‐signaling molecules produced by the maternal oviduct and endometrium. Here, datasets on the transcriptome of the gestational Days 5 and 6 bovine morula and Day 5 maternal endometrium were examined to identify receptor genes expressed by the morula and...

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Bibliographic Details
Published in:Molecular reproduction and development 2021-10, Vol.88 (10), p.694-704
Main Authors: Sang, Lei, Xiao, Yao, Jiang, Zongliang, Forde, Niamh, Tian, Xiuchun Cindy, Lonergan, Patrick, Hansen, Peter J.
Format: Article
Language:English
Subjects:
Cell signaling
Chemokines
Connective tissue growth factor
Cytokines
embryo
Embryogenesis
Endometrium
Growth factors
Hedgehog protein
Ligands
LRP2 protein
morula
Oviduct
Progesterone
receptors
Tissue inhibitor of metalloproteinase 1
Transcriptomes
Uterus
Wnt protein
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Summary:Regulation of the mammalian embryo involves cell‐signaling molecules produced by the maternal oviduct and endometrium. Here, datasets on the transcriptome of the gestational Days 5 and 6 bovine morula and Day 5 maternal endometrium were examined to identify receptor genes expressed by the morula and expression of the corresponding ligand‐related genes in the endometrium. A total of 175 receptor genes were identified in the morula, including 48 encoding for growth factors or WNT signaling molecules, 25 for cytokines and chemokines, 35 involved in juxtacrine and matricellular signaling and 25 encoding for receptors for small molecules. Some of the highly‐expressed pairs of endometrial ligand and embryo receptor genes included MDK and its receptors ITGB1, SDC4 and LRP2, WNT5A (RYK), VEGFA (ITGB1), GPI (AMFR), and the hedgehog proteins IHH and DHH (HHIP). The most highly expressed receptors for small molecules were GPRC5C (retinoic acid receptor), PGRMC1 (progesterone), and CHRNB2 (acetylcholine). There were also 84 genes encoding for cell signaling ligands expressed by the morula, with the most highly expressed being GPI, AIMP1, TIMP1, IK, and CCN2. The atlas of receptor and ligand genes should prove useful for understanding details of the communication between the embryo and mother that underlies optimal embryonic development.
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.23534