Thyroid Feedback Quantile-based Index correlates strongly to renal function in euthyroid individuals

Previous studies have reported a negative relationship between thyroid-stimulating hormone (TSH) and renal function in euthyroid individuals, but others have found that higher free thyroxine (FT 4 ) was associated with an increased risk of chronic kidney disease. This study was designed to analyze t...

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Bibliographic Details
Published in:Annals of medicine (Helsinki) 2021-01, Vol.53 (1), p.1945-1955
Main Authors: Yang, Sijue, Lai, Shuiqing, Wang, Zixiao, Liu, Aihua, Wang, Wei, Guan, Haixia
Format: Article
Language:English
Subjects:
Endocrinology
Euthyroid individuals
Feedback
Humans
Kidney - physiology
renal function
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Retrospective Studies
sensitivity to thyroid hormone
thyroid feedback quantile-based index
Thyroid Gland
Thyroid Hormones - blood
Thyrotropin
Thyroxine - blood
Triiodothyronine
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Summary:Previous studies have reported a negative relationship between thyroid-stimulating hormone (TSH) and renal function in euthyroid individuals, but others have found that higher free thyroxine (FT 4 ) was associated with an increased risk of chronic kidney disease. This study was designed to analyze the relationship between thyroid and renal function from a new perspective of sensitivity to thyroid hormone. This retrospective study included 2831 euthyroid individuals who underwent a health examination at the First Hospital of China Medical University between January 2017 and December 2018. Parametric Thyroid Feedback Quantile-based Index (PTFQI FT4 ), TSH index (TSHI), thyrotroph T 4 resistance index (TT 4 RI), free triiodothyronine to FT 4 ratio (FT 3 /FT 4 ), the secretory capacity of the thyroid gland (SPINA-GT) and the sum activity of peripheral deiodinases (SPINA-GD) were calculated. We also innovated the TT 3 RI and PTFQI FT3 indices based on FT 3 and TSH. Renal function was assessed by estimated glomerular filtration rate (eGFR) CKD-EPI and creatinine-cystatin C-KDIGO equations. After adjustment of basic characteristics and comorbidities, linear regression showed that eGFR CKD-EPI was positively associated with FT 3 /FT 4 (β = 23.31), and inversely correlated to PTFQI FT4 (β= −2.69) (both p 
ISSN:0785-3890
1365-2060
DOI:10.1080/07853890.2021.1993324