Loading…
Allium sativum aqueous extract does not have chemo-protective effect on etoposide induced therapy-related DNA damage leading to Acute Myeloid Leukemia in albino-wistar rats
Therapy-related acute myeloid leukemia (t-AML) is a well-recognized clinical syndrome occurring in a significant fraction of patients who have undergone previous chemotherapy for a solid tumour. We aim to evaluate the effect of aqueous extract of fresh Allium sativum cloves on haematological paramet...
Saved in:
Published in: | African health sciences 2021-06, Vol.21 (2), p.673-682 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c276t-b349db350afc1c1dec71e3319a657cc7c03ea0168c700e52040b1d54bff1e7373 |
---|---|
cites | |
container_end_page | 682 |
container_issue | 2 |
container_start_page | 673 |
container_title | African health sciences |
container_volume | 21 |
creator | Ndiokwelu, Ugochi F Ogunkanmi, Liasu A Minari, Joseph B Uzoma, Ijeoma C |
description | Therapy-related acute myeloid leukemia (t-AML) is a well-recognized clinical syndrome occurring in a significant fraction of patients who have undergone previous chemotherapy for a solid tumour.
We aim to evaluate the effect of aqueous extract of fresh Allium sativum cloves on haematological parameters, bone marrow and DNA of etoposide treated albino wistar rats. Decoction method was used to prepare plant extracts and the rats were weighed and divided into experimental and control groups. Blood and bone marrow sample were analysed and DNA fragment analysis was carried out.
There was progressive increase in the weight of animals that received distilled water only for the duration of the experiment while those that received etoposide only showed a sharp decrease in weight by the end of week 3. There was no significant difference in the mean of the haematological parameters in the test and control groups except for platelet count. The bone marrow smears showed no prevention of erythroblast fragmentation by the extract, in the same vein, DNA damage was not abated.
Aqueous extract of fresh Allium sativum cloves may not be the option for the prevention of etoposide induced acute myeloid leukemia. |
doi_str_mv | 10.4314/ahs.v21i2.24 |
format | article |
fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8568208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>34795722</sourcerecordid><originalsourceid>FETCH-LOGICAL-c276t-b349db350afc1c1dec71e3319a657cc7c03ea0168c700e52040b1d54bff1e7373</originalsourceid><addsrcrecordid>eNpVUcuO1DAQjBCIXRZunFF_ABn8SOLJBWm0PKXZ3QucrY7dmRiSONjOwPwTH4lhYbWcqlpdXS1VFcVzzjaV5NUrHOLmKLgTG1E9KM65Em3JaiYfZt5sWdm0rD4rnsT4hTHR8JY_Ls5kpdpaCXFe_NyNo1sniJjcMSN-W8mvEehHCmgSWE8RZp9gwCOBGWjy5RJ8IpP1BNT3mYGfgZJffHSWwM12NWQhDRRwOZWBRkx5fnO9A4sTHghGQuvmAyQPO7MmgqsTjd5Z2NP6lSaH2QRw7Nzsy-8uJgwQMMWnxaMex0jP_uJF8fnd20-XH8r9zfuPl7t9aYRqUtnJqrWdrBn2hhtuyShOUvIWm1oZowyThCyHYxRjVAtWsY7buur6npOSSl4Ur299l7WbyBqacxijXoKbMJy0R6f_38xu0Ad_1Nu62Qq2zQYvbw1M8DEG6u9uOdO_W9O5Nf2nNS2qLH9x_9-d-F9N8heOcJm3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Allium sativum aqueous extract does not have chemo-protective effect on etoposide induced therapy-related DNA damage leading to Acute Myeloid Leukemia in albino-wistar rats</title><source>PubMed Central</source><creator>Ndiokwelu, Ugochi F ; Ogunkanmi, Liasu A ; Minari, Joseph B ; Uzoma, Ijeoma C</creator><creatorcontrib>Ndiokwelu, Ugochi F ; Ogunkanmi, Liasu A ; Minari, Joseph B ; Uzoma, Ijeoma C</creatorcontrib><description>Therapy-related acute myeloid leukemia (t-AML) is a well-recognized clinical syndrome occurring in a significant fraction of patients who have undergone previous chemotherapy for a solid tumour.
We aim to evaluate the effect of aqueous extract of fresh Allium sativum cloves on haematological parameters, bone marrow and DNA of etoposide treated albino wistar rats. Decoction method was used to prepare plant extracts and the rats were weighed and divided into experimental and control groups. Blood and bone marrow sample were analysed and DNA fragment analysis was carried out.
There was progressive increase in the weight of animals that received distilled water only for the duration of the experiment while those that received etoposide only showed a sharp decrease in weight by the end of week 3. There was no significant difference in the mean of the haematological parameters in the test and control groups except for platelet count. The bone marrow smears showed no prevention of erythroblast fragmentation by the extract, in the same vein, DNA damage was not abated.
Aqueous extract of fresh Allium sativum cloves may not be the option for the prevention of etoposide induced acute myeloid leukemia.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>EISSN: 1680-6905</identifier><identifier>DOI: 10.4314/ahs.v21i2.24</identifier><identifier>PMID: 34795722</identifier><language>eng</language><publisher>Uganda: Makerere Medical School</publisher><subject>Animals ; Antioxidants - pharmacology ; Bone Marrow - drug effects ; DNA Damage - drug effects ; Etoposide - adverse effects ; Garlic - metabolism ; Leukemia, Myeloid, Acute - chemically induced ; Oxidative Stress - drug effects ; Plant Extracts - metabolism ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar</subject><ispartof>African health sciences, 2021-06, Vol.21 (2), p.673-682</ispartof><rights>2021 Ndiokwelu UF et al.</rights><rights>2021 Ndiokwelu UF et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c276t-b349db350afc1c1dec71e3319a657cc7c03ea0168c700e52040b1d54bff1e7373</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568208/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568208/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34795722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ndiokwelu, Ugochi F</creatorcontrib><creatorcontrib>Ogunkanmi, Liasu A</creatorcontrib><creatorcontrib>Minari, Joseph B</creatorcontrib><creatorcontrib>Uzoma, Ijeoma C</creatorcontrib><title>Allium sativum aqueous extract does not have chemo-protective effect on etoposide induced therapy-related DNA damage leading to Acute Myeloid Leukemia in albino-wistar rats</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Therapy-related acute myeloid leukemia (t-AML) is a well-recognized clinical syndrome occurring in a significant fraction of patients who have undergone previous chemotherapy for a solid tumour.
We aim to evaluate the effect of aqueous extract of fresh Allium sativum cloves on haematological parameters, bone marrow and DNA of etoposide treated albino wistar rats. Decoction method was used to prepare plant extracts and the rats were weighed and divided into experimental and control groups. Blood and bone marrow sample were analysed and DNA fragment analysis was carried out.
There was progressive increase in the weight of animals that received distilled water only for the duration of the experiment while those that received etoposide only showed a sharp decrease in weight by the end of week 3. There was no significant difference in the mean of the haematological parameters in the test and control groups except for platelet count. The bone marrow smears showed no prevention of erythroblast fragmentation by the extract, in the same vein, DNA damage was not abated.
Aqueous extract of fresh Allium sativum cloves may not be the option for the prevention of etoposide induced acute myeloid leukemia.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Bone Marrow - drug effects</subject><subject>DNA Damage - drug effects</subject><subject>Etoposide - adverse effects</subject><subject>Garlic - metabolism</subject><subject>Leukemia, Myeloid, Acute - chemically induced</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1680-6905</issn><issn>1729-0503</issn><issn>1680-6905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVUcuO1DAQjBCIXRZunFF_ABn8SOLJBWm0PKXZ3QucrY7dmRiSONjOwPwTH4lhYbWcqlpdXS1VFcVzzjaV5NUrHOLmKLgTG1E9KM65Em3JaiYfZt5sWdm0rD4rnsT4hTHR8JY_Ls5kpdpaCXFe_NyNo1sniJjcMSN-W8mvEehHCmgSWE8RZp9gwCOBGWjy5RJ8IpP1BNT3mYGfgZJffHSWwM12NWQhDRRwOZWBRkx5fnO9A4sTHghGQuvmAyQPO7MmgqsTjd5Z2NP6lSaH2QRw7Nzsy-8uJgwQMMWnxaMex0jP_uJF8fnd20-XH8r9zfuPl7t9aYRqUtnJqrWdrBn2hhtuyShOUvIWm1oZowyThCyHYxRjVAtWsY7buur6npOSSl4Ur299l7WbyBqacxijXoKbMJy0R6f_38xu0Ad_1Nu62Qq2zQYvbw1M8DEG6u9uOdO_W9O5Nf2nNS2qLH9x_9-d-F9N8heOcJm3</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Ndiokwelu, Ugochi F</creator><creator>Ogunkanmi, Liasu A</creator><creator>Minari, Joseph B</creator><creator>Uzoma, Ijeoma C</creator><general>Makerere Medical School</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20210601</creationdate><title>Allium sativum aqueous extract does not have chemo-protective effect on etoposide induced therapy-related DNA damage leading to Acute Myeloid Leukemia in albino-wistar rats</title><author>Ndiokwelu, Ugochi F ; Ogunkanmi, Liasu A ; Minari, Joseph B ; Uzoma, Ijeoma C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-b349db350afc1c1dec71e3319a657cc7c03ea0168c700e52040b1d54bff1e7373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Bone Marrow - drug effects</topic><topic>DNA Damage - drug effects</topic><topic>Etoposide - adverse effects</topic><topic>Garlic - metabolism</topic><topic>Leukemia, Myeloid, Acute - chemically induced</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ndiokwelu, Ugochi F</creatorcontrib><creatorcontrib>Ogunkanmi, Liasu A</creatorcontrib><creatorcontrib>Minari, Joseph B</creatorcontrib><creatorcontrib>Uzoma, Ijeoma C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ndiokwelu, Ugochi F</au><au>Ogunkanmi, Liasu A</au><au>Minari, Joseph B</au><au>Uzoma, Ijeoma C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allium sativum aqueous extract does not have chemo-protective effect on etoposide induced therapy-related DNA damage leading to Acute Myeloid Leukemia in albino-wistar rats</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>21</volume><issue>2</issue><spage>673</spage><epage>682</epage><pages>673-682</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><eissn>1680-6905</eissn><abstract>Therapy-related acute myeloid leukemia (t-AML) is a well-recognized clinical syndrome occurring in a significant fraction of patients who have undergone previous chemotherapy for a solid tumour.
We aim to evaluate the effect of aqueous extract of fresh Allium sativum cloves on haematological parameters, bone marrow and DNA of etoposide treated albino wistar rats. Decoction method was used to prepare plant extracts and the rats were weighed and divided into experimental and control groups. Blood and bone marrow sample were analysed and DNA fragment analysis was carried out.
There was progressive increase in the weight of animals that received distilled water only for the duration of the experiment while those that received etoposide only showed a sharp decrease in weight by the end of week 3. There was no significant difference in the mean of the haematological parameters in the test and control groups except for platelet count. The bone marrow smears showed no prevention of erythroblast fragmentation by the extract, in the same vein, DNA damage was not abated.
Aqueous extract of fresh Allium sativum cloves may not be the option for the prevention of etoposide induced acute myeloid leukemia.</abstract><cop>Uganda</cop><pub>Makerere Medical School</pub><pmid>34795722</pmid><doi>10.4314/ahs.v21i2.24</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1680-6905 |
ispartof | African health sciences, 2021-06, Vol.21 (2), p.673-682 |
issn | 1680-6905 1729-0503 1680-6905 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8568208 |
source | PubMed Central |
subjects | Animals Antioxidants - pharmacology Bone Marrow - drug effects DNA Damage - drug effects Etoposide - adverse effects Garlic - metabolism Leukemia, Myeloid, Acute - chemically induced Oxidative Stress - drug effects Plant Extracts - metabolism Plant Extracts - pharmacology Rats Rats, Wistar |
title | Allium sativum aqueous extract does not have chemo-protective effect on etoposide induced therapy-related DNA damage leading to Acute Myeloid Leukemia in albino-wistar rats |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T15%3A30%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allium%20sativum%20aqueous%20extract%20does%20not%20have%20chemo-protective%20effect%20on%20etoposide%20induced%20therapy-related%20DNA%20damage%20leading%20to%20Acute%20Myeloid%20Leukemia%20in%20albino-wistar%20rats&rft.jtitle=African%20health%20sciences&rft.au=Ndiokwelu,%20Ugochi%20F&rft.date=2021-06-01&rft.volume=21&rft.issue=2&rft.spage=673&rft.epage=682&rft.pages=673-682&rft.issn=1680-6905&rft.eissn=1729-0503&rft_id=info:doi/10.4314/ahs.v21i2.24&rft_dat=%3Cpubmed_cross%3E34795722%3C/pubmed_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c276t-b349db350afc1c1dec71e3319a657cc7c03ea0168c700e52040b1d54bff1e7373%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/34795722&rfr_iscdi=true |