Circulatory microRNA expression profile for coronary artery calcification in chronic kidney disease patients

Coronary artery disease (CAD) is the primary cause of mortality in patients with end stage renal disease (ESRD). MicroRNA profiling is proven as a powerful tool in the diagnosis of any disease at the molecular level. Hence, the present study aimed to profile the microRNA expression for CAD especiall...

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Bibliographic Details
Published in:African health sciences 2021-06, Vol.21 (2), p.728-734
Main Authors: Vijayaraghavan, Bhooma, Jeyamohan, Sridharan, Padmanabhan, Giri, Velangann, Antony Joseph, Ramanathan, Kumaresan
Format: Article
Language:English
Subjects:
Aged
Calcinosis - physiopathology
Coronary Artery Disease - genetics
Gene Expression
Humans
Kidney Failure, Chronic
MicroRNAs - blood
Middle Aged
Vascular Calcification - genetics
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Summary:Coronary artery disease (CAD) is the primary cause of mortality in patients with end stage renal disease (ESRD). MicroRNA profiling is proven as a powerful tool in the diagnosis of any disease at the molecular level. Hence, the present study aimed to profile the microRNA expression for CAD especially coronary artery calcification in CKD patients. Two hundread patients with CKD stages 3 to 5 without dialysis and healthy controls were included in this study. All two hundred patients underwent 1024 multi sliceardiac computed tomography (CT) scan for calcium scoring. The calcium scoring more than 100 have been included in the study. We performed miRNA microarray analysis from serum samples of seven high calcium scored with CKD patients and one control patients. Seven patients have observed circulating miRNAs has significantly upregulated and downregulated when compared with control patients. mir21, mir 67, mir 390, mir 56, mir 250, mir 65 and mir 13 were up regulated and mir235, mir256, mir226, mir207, mir255, mir193 were downregulated. There was no significant difference in left ventricle function. 13 microRNAs play a potential role in coronary artery calcification in CKD patients.
ISSN:1680-6905
1729-0503
1680-6905
DOI:10.4314/ahs.v21i2.31