Serum leptin is associated with increased pulse pressure and the development of arterial stiffening in adult men: results of an eight-year follow-up study

High leptin levels are associated with an unfavorable cardiometabolic risk profile. A number of studies found a positive association between leptin and vascular damage, but to date, no observational study has evaluated a potential predictive role of leptin for arterial stiffening. Therefore, the aim...

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Bibliographic Details
Published in:Hypertension research 2021-11, Vol.44 (11), p.1444-1450
Main Authors: D'Elia, Lanfranco, Giaquinto, Alfonso, Iacone, Roberto, Russo, Ornella, Strazzullo, Pasquale, Galletti, Ferruccio
Format: Article
Language:English
Subjects:
Adult
Adults
Blood Pressure
Cardiovascular disease
Epidemiology
Follow-Up Studies
Humans
Hypertension
Leptin
Male
Mens health
Metabolic disorders
Middle Aged
Prospective Studies
Risk Factors
Vascular Stiffness
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Summary:High leptin levels are associated with an unfavorable cardiometabolic risk profile. A number of studies found a positive association between leptin and vascular damage, but to date, no observational study has evaluated a potential predictive role of leptin for arterial stiffening. Therefore, the aim of this study was to estimate the role of leptin in the incidence of arterial stiffening (pulse pressure >60 mmHg) and changes in pulse pressure in an 8-year follow-up of a sample of adult men (The Olivetti Heart Study). The analysis included 460 men without baseline arterial stiffening and antihypertensive treatment at baseline and at follow-up (age: 50.0 years, BMI: 26.5 kg/m ). At the end of the follow-up period, the incidence of arterial stiffening was 8%. Baseline leptin was significantly greater in the group that developed arterial stiffening and was significantly correlated with pulse pressure changes over time (p 
ISSN:0916-9636
1348-4214
DOI:10.1038/s41440-021-00718-x