Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia

We present the case of a patient in the third decade of life, with asthma as comorbidity, who presented to the emergency department due to odynophagia, dyspnea, and cough of 2 days of evolution, later developing acute ventilatory failure requiring orotracheal intubation. The high-resolution chest to...

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Bibliographic Details
Published in:Journal of neurovirology 2021-12, Vol.27 (6), p.960-965
Main Authors: Palacio-Toro, María A., Hernández-Botero, Johan S., Duque-Montoya, Daniela, Osorio, Yuly, Echeverry, Alejandro, Osorio-Maldonado, Johanna J., Orjuela-Rodríguez, Marcela, Rodríguez-Morales, Alfonso J.
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Case Report
Colombia
COVID-19 - complications
Humans
Immunology
Infectious Diseases
Meningoencephalitis - diagnosis
Meningoencephalitis - diagnostic imaging
Neurology
Neurosciences
SARS-CoV-2
Seizures
Virology
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Summary:We present the case of a patient in the third decade of life, with asthma as comorbidity, who presented to the emergency department due to odynophagia, dyspnea, and cough of 2 days of evolution, later developing acute ventilatory failure requiring orotracheal intubation. The high-resolution chest tomography study showed consolidation due to a pneumonic process towards the posterior segment of the right lower lobe with areas of ground-glass infiltrates with a peripheral distribution. During the clinical course, the patient presented multiple seizure episodes that met the criteria for status epilepticus with MRI compatible with changes due to leptomeningitis. Given symptoms and thorax imaging, tests for SARS-CoV-2 ensued, with both positive RT-PCR in bronchoalveolar lavage and cerebrospinal fluid for the virus also positive. RT-PCR multiplex panel of meningitis/encephalitis results negative for 14 common organisms. A diagnosis of acute meningoencephalitis associated with COVID-19 was considered, with an adequate response to corticosteroid management; to our knowledge, this is the first adult patient with CNS involvement and CSF positive test in Latin America.
ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-021-01023-6