Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy

Ischemia-reperfusion injury (IRI) is defined as the total combined damage that occurs during a period of ischemia and following the recovery of blood flow. Oxidative stress, mitochondrial dysfunction, and an inflammatory response are factors contributing to IRI-related damage that can each result in...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.5391706-5391706
Main Authors: Wang, Yani, Liu, Huibin, Sun, Na, Li, Jing, Peng, Xiang, Jia, Ying, Karch, Jason, Yu, Bo, Wehrens, Xander H. T., Tian, Jinwei
Format: Article
Language:English
Subjects:
Adenosine
Angioplasty
Animals
Biology
Biomarkers
Cardiovascular disease
Chronic obstructive pulmonary disease
Fibronectins - antagonists & inhibitors
Fibronectins - metabolism
Free radicals
Grants
Hematology
Humans
Ischemia
Kinases
Laboratories
Medicine
Metabolism
Nephrology
Nitric oxide
Oxidative Stress
Pathogenesis
Pathophysiology
Permeability
Physiology
Proteins
Reperfusion Injury - metabolism
Reperfusion Injury - pathology
Reperfusion Injury - therapy
Review
Sickle cell disease
Tumor necrosis factor-TNF
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Summary:Ischemia-reperfusion injury (IRI) is defined as the total combined damage that occurs during a period of ischemia and following the recovery of blood flow. Oxidative stress, mitochondrial dysfunction, and an inflammatory response are factors contributing to IRI-related damage that can each result in cell death. Irisin is a polypeptide that is proteolytically cleaved from the extracellular domain of fibronectin type III domain-containing protein 5 (FNDC5). Irisin acts as a myokine that potentially mediates beneficial effects of exercise by reducing oxidative stress, improving mitochondrial fitness, and suppressing inflammation. The existing literature also suggests a possible link between irisin and IRI, involving mechanisms similar to those associated with exercise. This article will review the pathogenesis of IRI and the potential benefits and current limitations of irisin as a therapeutic strategy for IRI, while highlighting the mechanistic correlations between irisin and IRI.
ISSN:1942-0900
1942-0994
DOI:10.1155/2021/5391706