Safety and Toxicity Issues of Therapeutically Used Nanoparticles from the Oral Route

The emerging science of nanotechnology sparked a research attention in its potential benefits in comparison to the conventional materials used. Oral products prepared via nanoparticles (NPs) have garnered great interest worldwide. They are used commonly to incorporate nutrients and provide antimicro...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021 (1), p.9322282
Main Authors: Lotfipour, Farzaneh, Shahi, Shahriar, Farjami, Afsaneh, Salatin, Sara, Mahmoudian, Mohammad, Dizaj, Solmaz Maleki
Format: Article
Language:English
Subjects:
Administration, Oral
Analysis
Animals
Antiinfectives and antibacterials
Antimicrobial activity
Bioavailability
Biological Availability
Cell culture
Controlled release
Dental materials
Design
Drug Carriers
Drug delivery
Drug delivery systems
Drug Delivery Systems - trends
Drug Stability
Drugs
Gastrointestinal tract
Health aspects
Humans
Metabolism
Methods
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - adverse effects
Nanotechnology
Nutrients
Oral administration
Permeability
Pharmaceutical chemistry
Physiology
Properties
Review
Safety
Small intestine
Solubility
Sustained release
Technology application
Toxicity
Vehicles
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Summary:The emerging science of nanotechnology sparked a research attention in its potential benefits in comparison to the conventional materials used. Oral products prepared via nanoparticles (NPs) have garnered great interest worldwide. They are used commonly to incorporate nutrients and provide antimicrobial activity. Formulation into NPs can offer opportunities for targeted drug delivery, improve drug stability in the harsh environment of the gastrointestinal (GI) tract, increase drug solubility and bioavailability, and provide sustained release in the GI tract. However, some issues like the management of toxicity and safe handling of NPs are still debated and should be well concerned before their application in oral preparations. This article will help the reader to understand safety issues of NPs in oral drug delivery and provides some recommendations to the use of NPs in the drug industry.
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/9322282