Targeting PINK1 Using Natural Products for the Treatment of Human Diseases

PINK1, also known as PARK6, is a PTEN-induced putative kinase 1 that is encoded by nuclear genes. PINK1 is ubiquitously expressed and regulates mitochondrial function and mitophagy in a range of cell types. The dysregulation of PINK1 is associated with the pathogenesis and development of mitochondri...

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Bibliographic Details
Published in:BioMed research international 2021-10, Vol.2021, p.4045819-10
Main Authors: Li, Yan-Qin, Zhang, Fan, Yu, Li-Ping, Mu, Jian-Kang, Yang, Ya-Qin, Yu, Jie, Yang, Xing-Xin
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Animals
Apoptosis
Autophagy
Autophagy (Cytology)
Biological Products - metabolism
Biological Products - pharmacology
Biomedical research
Cardiovascular diseases
Care and treatment
Coronary artery disease
Cytoplasm
Diagnosis
Disease
DNA damage
Drug Therapy - methods
Health services
Heart diseases
Hepatitis
Humans
Kinases
Liver cancer
Liver diseases
Localization
Metabolism
Mitochondria
Mitochondria - metabolism
Mitochondrial diseases
Mitochondrial Diseases - drug therapy
Mitophagy
Movement disorders
Musculoskeletal system
Mutation
Natural products
Neurodegenerative diseases
NMR
Nuclear magnetic resonance
Oxidative stress
Parkinson's disease
Pathogenesis
Physiology
Protein kinases
Protein Kinases - drug effects
Protein Kinases - genetics
Protein Kinases - metabolism
Protein Kinases - physiology
Proteins
PTEN protein
PTEN-induced putative kinase
Quality control
Review
Risk factors
Structure-function relationships
Tumorigenesis
Ubiquitin-Protein Ligases - metabolism
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Summary:PINK1, also known as PARK6, is a PTEN-induced putative kinase 1 that is encoded by nuclear genes. PINK1 is ubiquitously expressed and regulates mitochondrial function and mitophagy in a range of cell types. The dysregulation of PINK1 is associated with the pathogenesis and development of mitochondrial-associated disorders. Many natural products could regulate PINK1 to relieve PINK1-associated diseases. Here, we review the structure and function of PINK1, its relationship to human diseases, and the regulation of natural products to PINK1. We further highlight that the discovery of natural PINK1 regulators represents an attractive strategy for the treatment of PINK1-related diseases, including liver and heart diseases, cancer, and Parkinson’s disease. Moreover, investigating PINK1 regulation of natural products can enhance the in-depth comprehension of the mechanism of action of natural products.
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/4045819