The role of inflammatory indices in the outcome of COVID-19 cancer patients

• Published in: Medical oncology (Northwood, London, England) London, England), 2022-01, Vol.39 (1), p.6-6, Article 6
• Main Authors: Nooh, Hend A., Abdellateif, Mona S., Refaat, Lobna, Kandeel, Eman Z., Bayoumi, Ahmed, Samra, Mohamed, Khafagy, Medhat
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Blood Platelets - pathology; Cancer; Child; Child, Preschool; Coronaviruses; COVID-19; COVID-19 - pathology; Female; Hematology; Humans; Inflammation; Inflammation - pathology; Inflammation - virology; Internal Medicine; Leukocyte Count - methods; Lymphocytes; Lymphocytes - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasms - pathology; Neoplasms - virology; Neutrophils; Neutrophils - pathology; Oncology; Original Paper; Pathology; Pediatrics; Prognosis; Retrospective Studies; SARS-CoV-2 - pathogenicity; Sensitivity and Specificity; Young Adult
• ISSN: 1357-0560; 1559-131X
• DOI: 10.1007/s12032-021-01605-8

To assess the prognostic role of different inflammatory indices on the outcome of cancer patients with COVID-19. Sixty-two adults and 22 pediatric cancer patients with COVID-19 infection were assessed for the prognostic value of certain inflammatory indices including the neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), derived NLR (dNLR), systemic inflammation index (SII), mean platelet volume to platelet ratio (MPR), C-reactive protein to lymphocyte ratio (CRP/L), aggregate index of systemic inflammation (AISI), systemic inflammation response index (SIRI), and neutrophil to lymphocyte, platelet ratio (NLPR). Data were correlated to patients’ outcome regarding ICU admission, and incidence of mortality. Increased CRP/L ratio in adult COVID-19 cancer patients was significantly associated with inferior survival [152 (19–2253) in non-survivors, compared to 27.4 (0.8–681) in survivors ( P  = 0.033)]. It achieved a sensitivity (60%) and a specificity (90.2%) at a cut-off 152, while it achieved a sensitivity of 60% and specificity 95.1% at a cut-off 252 (AUC 0.795, P  = 0.033). When combining both CRP/L and NLPR for the prediction of poor outcome in adult cancer patients with COVID19, the sensitivity increased to 80% and the specificity was 70.7% (AUC 0.805, P  = 0.027). Increased incidence of ICU admission in pediatric cancer patients associated significantly with the severity of covid19 infection, decreased mean corpuscular hemoglobin (MCH)  16, lymphopenia