Identification of protein targets in red complex organisms binding with resveratrol

Periodontitis is attributed to the dental biofilm formation caused by various Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound resveratrol (E - 5...

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Bibliographic Details
Published in:Bioinformation 2020-11, Vol.16 (11), p.837-842
Main Author: Pothapur, Keshaav Krishnaa
Format: Article
Language:English
Subjects:
Benzene
Binding
Biofilms
Organisms
Periodontal diseases
Periodontitis
Proteins
Resveratrol
Target recognition
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Summary:Periodontitis is attributed to the dental biofilm formation caused by various Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound resveratrol (E - 5 - (4 - hydroxy styryl) benzene 1,3 diol). We report a list of potential proteins having optimal drug like binding features with the herbal agent Resveratrol for further consideration. We used the STITCH v.5 pipeline using VICMPred and VirulentPred tools to identify such targets as potential virulent factors in the red complex organisms. We considered the strains of Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 in the red complex pathogens for this analysis. Protein targets in the red complex organisms with optimal binding features with the herbal compound resveratrol were thus identified and reported for further consideration.
ISSN:0973-8894
0973-2063
0973-2063
DOI:10.6026/97320630016837