Fatal case of Trichoderma harzianum infection in a renal transplant recipient

We describe the second known case of human infection by Trichoderma harzianum. A disseminated fungal infection was detected in the postmortem examination of a renal transplant recipient and confirmed in culture. The only other reported infection by this fungus caused peritonitis in a diabetic patien...

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Bibliographic Details
Published in:Journal of clinical microbiology 1999-11, Vol.37 (11), p.3751-3755
Main Authors: GUARRO, J, ANTOLIN-AYALA, M. I, GENE, J, GUTIERREZ-CALZADA, J, NIEVES-DIEZ, C, ORTONEDA, M
Format: Article
Language:English
Subjects:
Aged
Antifungal Agents - pharmacology
Biological and medical sciences
Drug Resistance, Microbial
Fatal Outcome
Human mycoses
Humans
Immunocompromised Host
Infectious diseases
Kidney Transplantation - adverse effects
Male
Medical sciences
Microscopy, Electron, Scanning
Mycology
Mycology - methods
Mycoses
Mycoses - etiology
Mycoses - microbiology
Mycoses - pathology
Mycotic sepsis
Opportunistic Infections - etiology
Opportunistic Infections - microbiology
Opportunistic Infections - pathology
Trichoderma - classification
Trichoderma - isolation & purification
Trichoderma - pathogenicity
Trichoderma harzianum
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Summary:We describe the second known case of human infection by Trichoderma harzianum. A disseminated fungal infection was detected in the postmortem examination of a renal transplant recipient and confirmed in culture. The only other reported infection by this fungus caused peritonitis in a diabetic patient. The in vitro antifungal susceptibilities of the clinical strain and three other strains of Trichoderma species to six antifungal drugs are provided. This case illustrates the widening spectrum of opportunistic Trichoderma spp. in immunocompromised patients and emphasizes the problems in diagnosing invasive fungal diseases.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.37.11.3751-3755.1999