Evolving Bilateral Hypermetabolic Axillary Lymphadenopathy on FDG PET/CT Following 2-Dose COVID-19 Vaccination

A 50-year-old woman with stage IV sigmoid adenocarcinoma presented for restaging FDG PET/CT status post neoadjuvant chemotherapy/immunotherapy and diverting sigmoid colostomy. FDG PET/CT demonstrated FDG uptake in the known sigmoid mass and in abdominopelvic lymph node metastases. Bilateral, asymmet...

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Bibliographic Details
Published in:Clinical nuclear medicine 2021-12, Vol.46 (12), p.1011-1012
Main Authors: Weeks, Joanna K., O’Brien, Sophia R., Rosenspire, Karen C., Dubroff, Jacob G., Pantel, Austin R.
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 Vaccines
Female
Fluorodeoxyglucose F18
Humans
Interesting Images
Lymphadenopathy - diagnostic imaging
Lymphatic Metastasis
Middle Aged
Positron Emission Tomography Computed Tomography
SARS-CoV-2
Vaccination
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Summary:A 50-year-old woman with stage IV sigmoid adenocarcinoma presented for restaging FDG PET/CT status post neoadjuvant chemotherapy/immunotherapy and diverting sigmoid colostomy. FDG PET/CT demonstrated FDG uptake in the known sigmoid mass and in abdominopelvic lymph node metastases. Bilateral, asymmetric, hypermetabolic axillary lymphadenopathy was also observed, an atypical pattern of spread for colon cancer. Further investigation revealed the patient had received both doses of COVID-19 vaccine in the 2 months prior to presentation. The authors discuss immunogenic nodal hypermetabolism following vaccination against COVID-19 and incorporating vaccination history to aid in PET/CT interpretation, especially in malignancies involving the axillae.
ISSN:0363-9762
1536-0229
1536-0229
DOI:10.1097/RLU.0000000000003711