Mitochondria‑related TFAM gene variants and their effects on patients with cervical cancer

Cervical cancer is the fourth most common type of cancer in women worldwide, with high incidence and mortality rates, particularly in developing countries. There are human papillomavirus vaccines and cytological screening programs available; however, there are no molecular markers that would aid the...

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Bibliographic Details
Published in:Biomedical reports 2021-12, Vol.15 (6), p.1-106, Article 106
Main Authors: Golubickaite, Ieva, Ugenskiene, Rasa, Cepaite, Juste, Ziliene, Egle, Inciura, Arturas, Poskiene, Lina, Juozaityte, Elona
Format: Article
Language:English
Subjects:
Age
Apoptosis
Biomarkers
Cancer
Cervical cancer
Cervix
Developing countries
Development and progression
Diagnosis
DNA probes
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Genetic transcription
Genotype & phenotype
Genotyping
Human papillomavirus
Immunization
Industrialized nations
LDCs
Lithuania
Lymphatic system
Metabolism
Metastasis
Mitochondria
Mitochondrial DNA
Mortality
Nucleotides
Papillomavirus infections
Patients
Phenotypes
Prognosis
Regression analysis
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Survival analysis
Transcription factors
Tumors
Vaccines
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Summary:Cervical cancer is the fourth most common type of cancer in women worldwide, with high incidence and mortality rates, particularly in developing countries. There are human papillomavirus vaccines and cytological screening programs available; however, there are no molecular markers that would aid the prognosis of the course of the disease or prediction of the outcomes of the patients. The aim of the present study was to investigate the associations between single nucleotide polymorphisms (SNPs) of the mitochondrial transcription factor A (TFA M ) gene (rs110 06132, rs110 06129, rs1937, rs16912174, rs16912202 and rs3900887), and the clinical parameters and tumor phenotype of patients with cervical cancer. DNA isolated from patients with cervical cancer (n=172) was used for genotyping using Real-Time PCR using TaqMan probes. It was revealed that the TFAM rs3900887 TT and AT genotypes were associated with a lower risk of developing larger tumors. The results showed an association between the rs3900887 SNP and tumor phenotype, indicating TFAM rs3900887 as a potential biomarker for tumor size in cervical cancer.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2021.1482