Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins

Arsenic is widely present in the environment and is associated with various population health risks including cancers. Arsenic exposure at environmentally relevant levels enhances the mutagenic effect of other carcinogens such as ultraviolet radiation. Investigation on the molecular mechanisms could...

Full description

Saved in:
Bibliographic Details
Published in:Seminars in cancer biology 2021-11, Vol.76, p.86-98
Main Authors: Zhou, Xixi, Speer, Rachel M., Volk, Lindsay, Hudson, Laurie G., Liu, Ke Jian
Format: Article
Language:English
Subjects:
Animals
Arsenic
Arsenic - adverse effects
Co-carcinogenesis
Cocarcinogenesis - metabolism
Cocarcinogenesis - pathology
DNA repair
DNA Repair - drug effects
DNA Repair - physiology
Humans
ROS
Zinc finger
Zinc Fingers - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Arsenic is widely present in the environment and is associated with various population health risks including cancers. Arsenic exposure at environmentally relevant levels enhances the mutagenic effect of other carcinogens such as ultraviolet radiation. Investigation on the molecular mechanisms could inform the prevention and intervention strategies of arsenic carcinogenesis and co-carcinogenesis. Arsenic inhibition of DNA repair has been demonstrated to be an important mechanism, and certain DNA repair proteins have been identified to be extremely sensitive to arsenic exposure. This review will summarize the recent advances in understanding the mechanisms of arsenic carcinogenesis and co-carcinogenesis, including DNA damage induction and ROS generation, particularly how arsenic inhibits DNA repair through an integrated molecular mechanism which includes its interactions with sensitive zinc finger DNA repair proteins.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2021.05.009