The Risk of Malignancies in Celiac Disease—A Literature Review

Celiac disease (CeD) is an immune-mediated enteropathy precipitated by ingestion of gluten in genetically predisposed individuals. Considering that CeD affects approximately 1% of the Western population, it may be considered a global health problem. In the large majority of cases, CeD has a benign c...

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Bibliographic Details
Published in:Cancers 2021-10, Vol.13 (21), p.5288
Main Authors: Pelizzaro, Filippo, Marsilio, Ilaria, Fassan, Matteo, Piazza, Francesco, Barberio, Brigida, D’Odorico, Anna, Savarino, Edoardo V., Farinati, Fabio, Zingone, Fabiana
Format: Article
Language:English
Subjects:
Autoimmune diseases
Cancer
Celiac disease
Clinical aspects
Diet
Gluten
Life span
Literature reviews
Lymphocytes T
Lymphoma
Medical prognosis
Mortality
Population
Public health
Remission
Review
Serology
Small intestine
T-cell lymphoma
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Summary:Celiac disease (CeD) is an immune-mediated enteropathy precipitated by ingestion of gluten in genetically predisposed individuals. Considering that CeD affects approximately 1% of the Western population, it may be considered a global health problem. In the large majority of cases, CeD has a benign course, characterized by the complete resolution of symptoms and a normal life expectancy after the beginning of a gluten-free-diet (GFD); however, an increased risk of developing malignancies, such as lymphomas and small bowel carcinoma (SBC), has been reported. In particular, enteropathy-associated T-cell lymphoma (EATL), a peculiar type of T-cell lymphoma, is characteristically associated with CeD. Moreover, the possible association between CeD and several other malignancies has been also investigated in a considerable number of studies. In this paper, we aim to provide a comprehensive review of the current knowledge about the associations between CeD and cancer, focusing in particular on EATL and SBC, two rare but aggressive malignancies.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13215288