Delphinidin and Its Glycosides' War on Cancer: Preclinical Perspectives

Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycoside...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-10, Vol.22 (21), p.11500
Main Authors: Sharma, Anshul, Choi, Hyo-Kyoung, Kim, Yeon-Kye, Lee, Hae-Jeung
Format: Article
Language:English
Subjects:
Animals
Anthocyanins
Anthocyanins - chemistry
Anthocyanins - pharmacology
Anticarcinogenic Agents - pharmacology
Antineoplastic Agents - pharmacology
Antioxidants
Apoptosis
Bioavailability
Cancer
Carcinogenesis - drug effects
Cell growth
Cell Movement - drug effects
Cell Proliferation - drug effects
Dietary Supplements
Functional foods & nutraceuticals
Glycosides
Glycosides - chemistry
Glycosides - pharmacology
Glycosylation
Humans
Inflammation
Kinases
Metabolites
Mice
Molecular modelling
Neoplasms - drug therapy
Neoplasms - prevention & control
Prostate cancer
Proteins
Review
Tumors
Vascular endothelial growth factor
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Summary:Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycosides on various cancers and their plausible molecular mechanisms. Considerable evidence shows significant anticancer properties of delphinidin-rich preparations and delphinidin alone both in vitro and in vivo. This review covers the in vitro and preclinical implications of delphinidin-mediated cell protection and cancer prevention; thus, we strongly recommend that delphinidin-rich preparations be further investigated as potential functional food, dietary antioxidant supplements, and natural health products targeting specific chronic diseases, including cancer. In addition to in vitro investigations, future research should focus on more animal and human studies to determine the true potential of delphinidin.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222111500