Increase in the Antioxidant and Anti-Inflammatory Activity of Euterpe oleracea Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin

• Published in: International journal of molecular sciences 2021-10, Vol.22 (21), p.11524
• Main Authors: de Almeida Magalhães, Thalita Sévia Soares, de Oliveira Macedo, Pollyana Cristina, da Costa, Érika Cibely Pinheiro, de Aragão Tavares, Emanuella, da Silva, Valéria Costa, Guerra, Gerlane Coelho Bernardo, Pereira, Joquebede Rodrigues, de Araújo Moura Lemos, Telma Maria, de Negreiros, Marília Medeiros Fernandes, de Oliveira Rocha, Hugo Alexandre, Converti, Attilio, de Lima, Ádley Antonini Neves
• Format: Article
• Language: English
• Subjects: 2-Hydroxypropyl-beta-cyclodextrin - administration & dosage; Acids; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antioxidants; Antioxidants - administration & dosage; Antioxidants - chemistry; Antioxidants - pharmacology; Arthritis; beta-Cyclodextrins - administration & dosage; Cyclodextrins; Cytokines; Diabetes mellitus; Edema; Edema - drug therapy; Enzymes; Euterpe - chemistry; Euterpe oleracea; Female; IL-1β; In Vitro Techniques; Inflammation; Interleukin 10; Male; Mice; Oil; Oxidative stress; Peroxidase; Phytochemicals - administration & dosage; Phytochemicals - chemistry; Phytochemicals - pharmacology; Plant Oils - administration & dosage; Plant Oils - chemistry; Plant Oils - pharmacology; Plants, Medicinal - chemistry; Reactive oxygen species; Rheumatoid arthritis; Scavenging; Slurries; β-Cyclodextrin
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms222111524

Reactive oxygen species (ROS) are aerobic products generated during cellular respiration, but in the case of oxidative stress, they become key factors in the development of inflammatory processes and chronic diseases such as diabetes and rheumatoid arthritis. In this work, oil (EOO), as well as the complexes produced by slurry (S) and kneading (K), were analyzed for antioxidant capacity in vitro, while only the β-cyclodextrin complex obtained by kneading (EOO-βCD-K), which showed better complexation, was selected for anti-inflammatory assays in vivo. In the scavenging activity of OH·, the hydroxypropyl-β-cyclodextrin complex obtained by kneading (EOO-HPβCD-K) exhibited an activity 437% higher than the pure oil. In the paw edema assay, EOO-βCD-K reduced edema by 200% and myeloperoxidase (MPO) activity by 112%. In an air pouch model, this treatment showed a reduction in leukocyte, MPO, and Interleukin-1β (IL-1β) levels; meanwhile those of glutathione and IL-10 were increased, demonstrating its ability to potentiate the anti-inflammatory effect of EOO.