Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists

Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for vario...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-11, Vol.22 (21), p.12077
Main Authors: Cid-Jofré, Valeska, Moreno, Macarena, Reyes-Parada, Miguel, Renard, Georgina M
Format: Article
Language:English
Subjects:
Addictions
Agonists
Amino acids
Animals
Antagonists
Anxiety disorders
Autism
Behavior
Blood-brain barrier
Brain research
Central nervous system
Central Nervous System Diseases - drug therapy
Central Nervous System Diseases - metabolism
Central Nervous System Diseases - pathology
Drug Agonism
Drug Antagonism
Gene expression
Homeostasis
Humans
Hypothalamus
Kinases
Ligands
Mental disorders
Mental Disorders - drug therapy
Mental Disorders - metabolism
Mental Disorders - pathology
Neuropeptides
NMR
Nuclear magnetic resonance
Oxytocics - therapeutic use
Oxytocin
Oxytocin - therapeutic use
Physical characteristics
Physical properties
Proteins
Review
Schizophrenia
Social behavior
Therapeutic targets
Vasoconstrictor Agents - therapeutic use
Vasopressin
Vasopressins - therapeutic use
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Summary:Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for various neuropsychiatric diseases such as autism, addiction, schizophrenia, depression, and anxiety disorders. Due to the chemical-physical characteristics of these neuropeptides including short half-life, poor blood-brain barrier penetration, promiscuity for AVP and OT receptors (AVP-R, OT-R), novel ligands have been developed in recent decades. This review summarizes the role of OT and AVP in neuropsychiatric conditions, as well as the findings of different OT-R and AVP-R agonists and antagonists, used both at the preclinical and clinical level. Furthermore, we discuss their possible therapeutic potential for central nervous system (CNS) disorders.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222112077