Structural and functional findings in patients with moderate diabetic retinopathy

Purpose To evaluate structural and functional ocular changes in patients with type 2 diabetes mellitus (DM2) and moderate diabetic retinopathy (DR) without apparent diabetic macular edema (DME) assessed by optical coherence tomography (OCT) and microperimetry. Methods This was a single-center cross-...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2021-12, Vol.259 (12), p.3625-3635
Main Authors: Boned-Murillo, A., Diaz-Barreda, M. D., Ferreras, A., Bartolomé-Sesé, I., Orduna-Hospital, E., Montes-Rodríguez, P., Ascaso, J., Pinilla, Isabel
Format: Article
Language:English
Subjects:
Acuity
Cross-Sectional Studies
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Edema
Hemoglobin
Humans
Macular Edema - diagnosis
Macular Edema - etiology
Medicine
Medicine & Public Health
Neurodegeneration
Ophthalmology
Retina
Retina - diagnostic imaging
Retinal Disorders
Retinopathy
Structure-function relationships
Tomography, Optical Coherence
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Summary:Purpose To evaluate structural and functional ocular changes in patients with type 2 diabetes mellitus (DM2) and moderate diabetic retinopathy (DR) without apparent diabetic macular edema (DME) assessed by optical coherence tomography (OCT) and microperimetry. Methods This was a single-center cross-sectional descriptive study for which 75 healthy controls and 48 DM2 patients with moderate DR were included after applying exclusion criteria (one eye per patient was included). All eyes underwent a complete ophthalmic examination (axial length, macular imaging with swept-source OCT, and MAIA microperimetry). Macular thicknesses, ganglion cell complex (GCC) thicknesses, and central retinal sensitivity were compared between groups, and the relationships between the OCT and microperimetry parameters were evaluated. Results Macular thickness was similar in both groups (242.17 ± 35.0 in the DM2 group vs 260.64 ± 73.9 in the control group). There was a diminution in the parafoveal area thickness in the DM2 group in the GCC complex. Retinal sensitivity was reduced in all sectors in the DM2 group. The central global value was 24.01 ± 5.7 in the DM2 group and 27.31 ± 2.7 in the control group (p 
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-021-05277-y