Magnetic resonance imaging, clinicopathologic findings, and clinical progression of a puppy with confirmed Eastern equine encephalitis virus

A 5-month-old puppy was evaluated for rapidly progressive neurologic signs and pyrexia. Magnetic resonance imaging showed multifocal meningoencephalitis with transtentorial and foramen magnum herniation. A cerebrospinal fluid tap revealed highly cellular fluid, and the puppy was euthanized. Histopat...

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Bibliographic Details
Published in:Canadian veterinary journal 2021-12, Vol.62 (12), p.1298-1303
Main Authors: Sun, Jessica A, Hallowell, Terry C
Format: Article
Language:English
Subjects:
Animals
Dog Diseases
Dogs
Encephalitis Virus, Eastern Equine
Encephalomyelitis, Eastern Equine - veterinary
Euthanasia, Animal
Horse Diseases - diagnostic imaging
Horses
Magnetic Resonance Imaging - veterinary
Meningoencephalitis - veterinary
Scientific
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Summary:A 5-month-old puppy was evaluated for rapidly progressive neurologic signs and pyrexia. Magnetic resonance imaging showed multifocal meningoencephalitis with transtentorial and foramen magnum herniation. A cerebrospinal fluid tap revealed highly cellular fluid, and the puppy was euthanized. Histopathology showed lymphoplasmacytic and neutrophilic meningoencephalitis. Viral polymerase chain reaction testing for Eastern equine encephalitis was positive. Rapid progression of neurologic signs and respiratory arrest necessitated mechanical ventilation. Severe hypernatremia, most consistent with central diabetes insipidus, developed. Key clinical message: Transtentorial and foramen magnum herniation and high cerebrospinal fluid cell counts may be indicators of poor prognosis. Brain death, respiratory arrest, and central diabetes insipidus may also ensue with Eastern equine encephalitis infection.
ISSN:0008-5286