The association between heart failure and incident cancer in women: an analysis of the Women's Health Initiative

• Published in: European journal of heart failure 2021-10, Vol.23 (10), p.1712-1721
• Main Authors: Leedy, Douglas J., Reding, Kerryn W., Vasbinder, Alexi L., Anderson, Garnet L., Barac, Ana, Wactawski‐Wende, Jean, Shadyab, Aladdin H., Eaton, Charles B., Levy, Wayne C., Qi, LiHong, Cheng, Richard K.
• Format: Article
• Language: English
• Subjects: Aged; Cancer; Cardio‐oncology; Female; Heart failure; Heart Failure - diagnosis; Heart Failure - epidemiology; Humans; Incidence; Male; Middle Aged; Neoplasms - epidemiology; Postmenopause; Prospective cohort; Prospective Studies; Risk; Risk Factors; Women's Health
• ISSN: 1388-9842; 1879-0844
• DOI: 10.1002/ejhf.2207

Aims There is conflicting evidence whether heart failure (HF) is a risk factor for incident cancer. Despite population‐based cohorts demonstrating this association, an analysis of the Physician's Health Study found no association in a cohort of mostly healthy males. We investigated the association of HF with incident cancer among a large cohort of post‐menopausal women. Methods and results A prospective cohort study of 146 817 post‐menopausal women age 50 to 79 years enrolled in the Women's Health Initiative from 1993–1998, and followed through 2015. The primary exposure was adjudicated incident HF diagnosis, including preserved and reduced ejection fraction in a sub‐cohort. The primary outcome was adjudicated incident total and site‐specific cancers. Hazard ratios were calculated using multivariable‐adjusted Cox proportional hazard regression models. Over a median follow‐up of 8.4 years, 3272 and 17 474 women developed HF and cancer, respectively. HF developed in 235 women prior to cancer. HF was associated with subsequent incident cancer [hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.11–1.48]. Associations were observed for obesity‐related cancers (HR 1.24, 95% CI 1.02–1.51), as well as lung and colorectal cancers (HR 1.58, 95% CI 1.09–2.30 and HR 1.52, 95% CI 1.02–2.27, respectively). HF with preserved ejection fraction (HR 1.34, 95% CI 1.06–1.67), but not HF reduced ejection fraction (HR 0.99, 95% CI 0.74–1.34), was associated with total cancer. Conclusion Heart failure was associated with an increase in cancer diagnoses in post‐menopausal women. This association was strongest for lung cancer. Further research is needed to appreciate the underlying mechanisms responsible for this association. Heart failure (HF) is significantly associated with an increased risk of developing cancer among post‐menopausal women. HFpEF, heart failure with preserved ejection fraction.