Potential role of marine species-derived bioactive agents in the management of SARS-CoV-2 infection

COVID-19, caused by the SARS-CoV-2 outbreak, has resulted in a massive global health crisis. Bioactive molecules extracted or synthesized using starting material obtained from marine species, including griffithsin, plitidepsin and fingolimod are in clinical trials to evaluate their anti-SARS-CoV-2 a...

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Bibliographic Details
Published in:Future microbiology 2021-11, Vol.16 (16), p.1289-1301
Main Authors: Asif, Muhammad, Saleem, Mohammad, Yaseen, Hafiza Sidra, Yehya, Ashwaq Hs, Saadullah, Malik, Zubair, Hafiz Muhammad, Oon, Chern E, Khaniabadi, Pegah Moradi, Khalid, Syed Haroon, Khan, Ikram Ullah, Mahrukh
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
anti-inflammatory
Anti-Inflammatory Agents
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
COVID-19
COVID-19 Drug Treatment
Depsipeptides
fingolimod
Fingolimod Hydrochloride - chemistry
Fingolimod Hydrochloride - pharmacology
griffithsin
Humans
Lectins
Marine Biology
marine drugs
Molecular Docking Simulation
Oceans and Seas
Peptides, Cyclic - chemistry
Peptides, Cyclic - pharmacology
Phycocyanin - pharmacology
Phytochemicals
Plant Lectins - chemistry
Plant Lectins - pharmacology
plitidepsin
Polyphenols - pharmacology
Polysaccharides - pharmacology
Review
SARS-CoV-2
SARS-CoV-2 - drug effects
Seaweed
Sesquiterpenes - pharmacology
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Summary:COVID-19, caused by the SARS-CoV-2 outbreak, has resulted in a massive global health crisis. Bioactive molecules extracted or synthesized using starting material obtained from marine species, including griffithsin, plitidepsin and fingolimod are in clinical trials to evaluate their anti-SARS-CoV-2 and anti-HIV efficacies. The current review highlights the anti-SARS-CoV-2 potential of marine-derived phytochemicals explored using ,  and models. The current literature suggests that these molecules have the potential to bind with various key drug targets of SARS-CoV-2. In addition, many of these agents have anti-inflammatory and immunomodulatory potentials and thus could play a role in the attenuation of COVID-19 complications. Overall, these agents may play a role in the management of COVID-19, but further preclinical and clinical studies are still required to establish their role in the mitigation of the current viral pandemic.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2021-0024