NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis

Lung cancer, which is exacerbated by environmental pollution and tobacco use, has become the most common cause of cancer-related deaths worldwide, with a five-year overall survival rate of only 19% (Siegel et al., 2020; Yang et al., 2020; Yu and Li, 2020). Nearly 85% of lung cancers are non-small ce...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2021-11, Vol.22 (11), p.959-965
Main Authors: Zhou, Lisha, Dong, Changsheng, Xu, Zhuoming, Wang, Xinran, Zhang, Luyi, Chen, Siyuan, Chen, Jiahao, Zhu, Yingying
Format: Article
Language:English
Subjects:
A549 Cells
Animals
Apoptosis
Biomedical and Life Sciences
Biomedicine
Correspondence
Female
HEK293 Cells
Humans
Lung cancer
Lung Neoplasms - metabolism
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - radiotherapy
Mice
Radiation
Radiation Tolerance
Reactive Oxygen Species - metabolism
Ubiquitin-Conjugating Enzymes - physiology
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Summary:Lung cancer, which is exacerbated by environmental pollution and tobacco use, has become the most common cause of cancer-related deaths worldwide, with a five-year overall survival rate of only 19% (Siegel et al., 2020; Yang et al., 2020; Yu and Li, 2020). Nearly 85% of lung cancers are non-small cell lung cancers, of which lung adenocarcinoma is the most common subtype accounting for 50% of non-small cell lung cancer cases. At present, radiotherapy is the primary therapeutic modality for lung cancer at different stages, with significant prolongation of survival time (Hirsch et al., 2017; Bai et al., 2019; Shi et al., 2020). Irradiation can generate reactive oxygen species (ROS) through the radiolysis reaction of water and oxygen, cause DNA damage and oxidative stress, and subsequently result in cancer cell death (Kim et al., 2019). Nevertheless, radioresistance seriously hinders the success of treatment for lung cancer, owing to local recurrence and distant metastasis (Huang et al., 2021). Compared with small cell lung cancer, non-small cell lung cancer shows more tolerance to radiotherapy. Therefore, it is of great importance to decipher key mechanisms of radioresistance and identify effective molecular radiosensitizers to improve patient survival.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B2100170