High‐risk HPV positivity is a long‐term risk factor for recurrence after cervical excision procedure in women living with HIV

Objective To evaluate the risk factors for recurrence of high‐grade disease after cervical excision in women living with HIV (WLWH), with a specific interest in the role of high‐risk (HR‐) HPV positivity. Methods Multicentric retrospective study conducted on WLWH who underwent cervical excision betw...

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Published in:International journal of gynecology and obstetrics 2021-12, Vol.155 (3), p.442-449
Main Authors: Agarossi, Alberto, Delli Carpini, Giovanni, Sopracordevole, Francesco, Serri, Matteo, Giannella, Luca, Gardella, Barbara, Maestri, Marta, Del Fabro, Anna, Sansone, Matilde, Fallani, Maria Grazia, Pieralli, Annalisa, Fasolo, Maria Michela, Mazzali, Cristina, Ciavattini, Andrea
Format: Article
Language:English
Subjects:
Adult
cervical excisional procedure
cervical intraepithelial neoplasia
Clinical
conization
Female
HIV
HIV Infections
Humans
Neoplasm Recurrence, Local - epidemiology
Papillomaviridae
Papillomavirus Infections
recurrence
Retrospective Studies
Risk Factors
Uterine Cervical Dysplasia
Uterine Cervical Neoplasms - surgery
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Summary:Objective To evaluate the risk factors for recurrence of high‐grade disease after cervical excision in women living with HIV (WLWH), with a specific interest in the role of high‐risk (HR‐) HPV positivity. Methods Multicentric retrospective study conducted on WLWH who underwent cervical excision between January 1987 and June 2017 in six Italian institutions. The rate of high‐grade recurrence was determined. Risk factors for recurrence and HR‐HPV positivity were determined with the Log‐rank test and Cox proportional hazards regression models. Results A total of 271 WLWH were included in the final analysis. A high‐grade recurrence was found in 58 (21.4%) patients. Age 41 years or more at inclusion and HR‐HPV positivity during follow up were independently associated with a higher risk of disease recurrence with relative risks of 4.15 (95% confidence interval [CI] 2.01–8.58, P 
ISSN:0020-7292
1879-3479
DOI:10.1002/ijgo.13674