The role of miR‐29 family in disease

MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3’‐untranslated region of messenger RNA to regulate posttranscriptional gene expression. Increasing evidence has identified the miR‐29 family, consisting of miR‐29a, miR‐29b‐1, miR‐29b‐2, and miR‐29c, as key regulators of a...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2021-07, Vol.122 (7), p.696-715
Main Authors: Horita, Masahiro, Farquharson, Colin, Stephen, Louise A
Format: Article
Language:English
Subjects:
3' Untranslated regions
Apoptosis
Biological activity
Biomedical materials
cardiorenal disease
Cardiovascular disease
Cell differentiation
Differentiation (biology)
Etiology
Fibrosis
Gene expression
immune disease
Immunological diseases
Kidney diseases
Lymphocytes
Lymphocytes T
microRNA
miRNA
miRNA‐29
mRNA
Osteoarthritis
Osteoblastogenesis
Osteoclastogenesis
Osteoporosis
Post-transcription
Review
Suppressors
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Summary:MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3’‐untranslated region of messenger RNA to regulate posttranscriptional gene expression. Increasing evidence has identified the miR‐29 family, consisting of miR‐29a, miR‐29b‐1, miR‐29b‐2, and miR‐29c, as key regulators of a number of biological processes. Moreover, their abnormal expression contributes to the etiology of numerous diseases. In the current review, we aimed to summarize the differential expression patterns and functional roles of the miR‐29 family in the etiology of diseases including osteoarthritis, osteoporosis, cardiorenal, and immune disease. Furthermore, we highlight the therapeutic potential of targeting members of miR‐29 family in these diseases. We present miR‐29s as promoters of osteoblast differentiation and apoptosis but suppressors of chondrogenic and osteoclast differentiation, fibrosis, and T cell differentiation, with clear avenues for therapeutic manipulation. Further research will be crucial to identify the precise mechanism of miR‐29 family in these diseases and their full potential in therapeutics. In the current review, we aimed to summarize the differential expression patterns and functional roles of the miR‐29 family in the etiology of diseases including osteoarthritis, osteoporosis, cardiorenal and immune disease. We present miR‐29s as promoters of osteoblast differentiation and apoptosis but suppressors of chondrogenic and osteoclast differentiation, fibrosis, and T cell differentiation.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.29896