Respiratory Function and Dysfunction in Parkinson-Type Neurodegeneration

Parkinson's disease (PD) is most commonly manifested by the presence of motor symptoms. However, non-motor symptoms occur several years before the onset of motor symptoms themselves. Hallmarks of dysfunction of the respiratory system are still outside the main focus of interest, whether by clin...

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Bibliographic Details
Published in:Physiological research 2020-03, Vol.69 (Suppl 1), p.S69-S79
Main Authors: Pokusa, M., Hajduchova, D., Budaj, T., Kralova Trancikova, A.
Format: Article
Language:English
Subjects:
Airway management
Alzheimer's disease
Animal models
Dysphagia
Dyspnea
Larynx
Morbidity
Mortality
Movement disorders
Neurodegeneration
Neurodegenerative diseases
Parkinson's disease
Patients
Pneumonia
Respiratory function
Respiratory system
Review
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Summary:Parkinson's disease (PD) is most commonly manifested by the presence of motor symptoms. However, non-motor symptoms occur several years before the onset of motor symptoms themselves. Hallmarks of dysfunction of the respiratory system are still outside the main focus of interest, whether by clinicians or scientists, despite their indisputable contribution to the morbidity and mortality of patients suffering from PD. In addition, many of the respiratory symptoms are already present in the early stages of the disease and efforts to utilize these parameters in the early diagnosis of PD are now intensifying. Mechanisms that lead to the development and progression of respiratory symptoms are only partially understood. This review focuses mainly on the comparison of respiratory problems observed in clinical studies with available findings obtained from experimental animal models. It also explains pathological changes observed in non-neuronal tissues in subjects with PD.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.934405