Exhaled and Nasal Nitric Oxide – Impact for Allergic Rhinitis

FeNO measurement is a validated non-invasive technique, which is used for diagnosis and monitoring of asthma. It would be desirable to find a reliable method to monitor allergic rhinitis (AR) via measurement of FeNO, and/or nasal nitric oxide (nNO). The aim of our study was the assessment of the eff...

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Bibliographic Details
Published in:Physiological research 2020-03, Vol.69 (Suppl 1), p.S123-S130
Main Authors: Antosova, M., Bencova, A., Mokra, D., Plevkova, J., Pepucha, L., Buday, T.
Format: Article
Language:English
Subjects:
Allergens
Allergic rhinitis
Allergies
Antihistamines
Asthma
Corticosteroids
Disease
Drug therapy
Gender differences
Histamine
Inflammation
Nitric oxide
Pollen
Population
Seasons
Womens health
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Summary:FeNO measurement is a validated non-invasive technique, which is used for diagnosis and monitoring of asthma. It would be desirable to find a reliable method to monitor allergic rhinitis (AR) via measurement of FeNO, and/or nasal nitric oxide (nNO). The aim of our study was the assessment of the efficacy of FeNO and nNO as markers in AR treatment. FeNO and nNO were measured with the portable NO analyser (NIOX MINO®) in healthy participants and in patients with AR. The patients were examined during the pollen season and out of it. The effect of local corticosteroids and antihistamine therapy was observed in patients with AR during pollen season after three weeks of therapy. There are significant differences between FeNO and nNO in patients with AR compared to healthy controls at all set points of measurements. While FeNO responded well to the treatment with both antihistamines and combined therapy, nNO decreased only after combined therapy with antihistamines and nasal corticosteroids. nNO monitoring alone is not a suitable method to monitor inflammation of the upper airways in AR and its suppression by anti-allergic treatment and should be correlated with other markers as FeNO or symptom scores.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.934393