SARS-CoV-2 IgG antibody responses in rt-PCR-positive cases: first report from India

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses remain poorly understood and the clinical utility of serological testing is still unclear. To understand the relationship between the antibody response to SARS-CoV-2 infection and the demographics and cycle threshold ( )...

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Published in:Access microbiology 2021, Vol.3 (10), p.000267-000267
Main Authors: Dash, Girish Chandra, Parai, Debaprasad, Choudhary, Hari Ram, Peter, Annalisha, Rout, Usha Kiran, Nanda, Rashmi Ranjan, Kshatri, Jaya Singh, Kanungo, Srikanta, Palo, Subrata Kumar, Mandal, Nityananda, Pati, Sanghamitra, Bhattacharya, Debdutta
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Language:English
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses remain poorly understood and the clinical utility of serological testing is still unclear. To understand the relationship between the antibody response to SARS-CoV-2 infection and the demographics and cycle threshold ( ) values of confirmed RT-PCR patients. A total of 384 serum samples were collected from individuals between 4-6 weeks after confirmed SARS-CoV-2 infection and tested for the development of immunoglobulin class G (IgG) against SARS-CoV-2. The values, age, gender and symptoms of the patients were correlated with the development of antibodies. IgG positivity was found to be 80.2 % (95 % CI, 76.2-84.2). Positivity increased with a decrease in the value, with the highest (87.6 %) positivity observed in individuals with values
ISSN:2516-8290
2516-8290
DOI:10.1099/acmi.0.000267